Aquaporins in Health and Disease:New Molecular Targets for Drug Discovery
健康与疾病方面的水通道蛋白:对药物发现的新分子靶点
医学生物化学This book presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function.