Microfluidics and Multi Organs on Chip

图书简介

This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Chapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.- Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.- Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.- Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.- Chapter 15. Liver on a chip.- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.- Chapter 20. Lungs on a chip.- Chapter 21. Brain on a chip.- Chapter 22. Skin on a chip.- Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.- Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.

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Microfluidics and Multi Organs on Chip 微流体与使用芯片的多器官 生物医学工程学

Microfluidics and Multi Organs on Chip

微流体与使用芯片的多器官
生物医学工程学