图书简介

New Chemistry in the Expanding Protein Universe: Novel Chemistry Still to be Found in Nature (C T Walsh); Natural Product Biosynthesis in the Genomic Age (W A van der Donk); Peptide Dendrimers and Polycyclic Peptides (J-L Reymond); What can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution? (N L Dawson, R Studer, N Furnham, D Lees, S Das, J Thornton and C Orengo); Exploring Chromatin Biology Using Protein Chemistry (T W Muir); Our Expanding Protein Universe (A Godzik); The Scientific Impact of Freely Available Chemical Probes (A M Edwards); Discussions of Session 1; Exploring Enzyme Families and Enzyme Catalysis: Mechanistic Enzymology and Catalyst Design (D Hilvert); Looking in New Directions for the Origins of Enzymatic Rate Accelerations (J P Klinman); Computational Enzyme Design and Methods to Predict the Role of Remote Mutations (K N Houk); Discovering Novel Enzymes, Metabolites and Pathways (J A Gerlt); Programming New Chemistry into the Genetic Code of Cells and Animals (J W Chin); Expanding the Enzyme Universe through a Marriage of Chemistry and Evolution (F H Arnold); Controlled Radical Reactions in Biology and the Importance of Metallo-Cofactor Biosynthesis (J Stubbe); Discussions of Session 2; Microbiomes and Carbohydrate Chemistry: Structural Basis for Host/Commensal-Microbe Interactions in the Human Distal Gut Microbiome (I A Wilson); Carbohydrate Chemistry and Biology (C-H Wong); Chemical Biological Proteomics of Bacterial Protein Functionalities in the Human Distal Gut Microbiome (D W Wolan); Automated Oligosaccharide Synthesis: From Insights into Fundamental Glycobiology to Vaccines and Diagnostics (P H Seeberger); Carbohydrate-Active Enzymes in Microbiomes (B Henrissat); The Microbiome(s): Microbiota, Families, Functions (A Godzik); N-Linked Protein Glycosylation (M Aebi); Discussions of Session 3; GPCRs and Transporters: Ligands, Cofactors, Drug Development: GPCRs and Transporters: Ligands, Cofactors, Drug Development (G von Heijne); Studies of GPCR Conformations in Non-Crystalline Milieus (K Wüthrich); The Seven Transmembrane Superfamily (R C Stevens); Nanobodies for the Structural and Functional Investigation of GPCR Transmembrane Signaling (E Pardon and J Steyaert); The Hidden Pharmacology of the Human GPCR-ome (B L Roth); Structures and Reaction Mechanisms of ABC Transporters (K Locher); Discussions of Session 4; Biologicals and Biosimilars: Biologicals and Biosimilars (S Ghose and M G Grütter); Platform Technologies for the Artificial Pseudo-Natural Product Discovery (H Suga); Anticalins® & Pasylation®: New Concepts for Biopharmaceutical Drug Development from Protein Design (A Skerra); From Natural Antibodies to Synthetic Proteins (S S Sidhu); From Intact Antibodies to Armed Antibodies (D Neri); Regulating Cellular Life Death and Development Using Intracellular Combinatorial Antibody Libraries (R Lerner, J Xie, H Zhang, K Yea, J Blanchard and K Baldwin); Nanobodies: A Universe of Variable Domains and a Toolbox for Many Trades (L Wyns); Discussions of Session 5; Proteins in Supramolecular Machines: Assembly of Filamentous Type 1 Pili from Uropathogenic Escherichia Coli Strains (R Glockshuber); HIV Envelope and Influenza Hemagglutinin Fusion Glycoproteins and the Quest for a Universal Vaccine (I A Wilson); Deconstruction of Iterative Polyketide Synthases (C A Townsend); Regulating Ribosome Pausing During Translation (M V Rodnina); The Molecular Mechanics of the Ribosome (J Zhou, L Lancaster, Z Guo, J P Donohue and H F Noller); Exploring the Dynamics of Supramolecular Machines with Cryo-Electron Microscopy (J Frank); Crystallographic Studies of Eukaryotic Ribosomes and Functional Insights (N Ban); Discussions of Session 6.

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