Resistance of Cancer Cells to CTL-Mediated Immunotherapy

CTL介导免疫治疗的癌细胞抵抗

肿瘤学

原   价:
1105
售   价:
884.00
优惠
平台大促 低至8折优惠
出版时间
2015年06月15日
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精装
ISBN
9783319178066
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语      种
英语
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图书简介
This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.
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