图书简介
This textbook is an important addition to the field because it will bring the research and clinical community up-to-date on the past, present and future direction for sickle cell disease (SCD) in the context of the Human Genome Project (HGP). There are a limited number of textbooks on SCD that covers the role of the four disciplines required to produce a successful cure of SCD. The volume begins with a history of the early efforts in SCD, the role of the federal government and a review of the HGP. Next, the major progress in clini
Sickle Cell Disease: Demystifying the Beginnings (C Reid & G Rodgers); Sponsorship of Sickle Cell Disease Research by the National Institutes of Health: A Brief History and Projections for the Future (G L Evans & D G Badman); The Human Genome Project (B S Pace); Sickle Cell Disease: A Phenotypic Patchwork (K Smith-Whitley & B S Pace); Preventive Care and Advances in the Treatment of Sickle Cell Disease (C T Quinn & G R Buchanan); Sickle Cell Disease in Adults (J Haynes, Jr. & A Pack-Mabien); Pain in Sickle Cell Disease: A Multidimensional Construct (L J Benjamin & R Payne); Transfusion Therapy in Sickle Cell Disease (C Hoppe et al.); Hemoglobin S Polymerization, Just the Beginning (F A Ferrone); Damage to the Red Blood Cell Membrane in Sickle Cell Disease (S R Goodman & C Joiner); Fetal Hemoglobin for What Ails Sickle Hemoglobin (S F Ofori-Acquah & B S Pace); Genetic Modulation of Sickle Cell Disease (M H Steinberg & L T Swee); Molecular Framework of Hemoglobin Switching (S Fiering); Dynamic Nucleoprotein Structure of the ß-Globin Locus: Establishing a Rational Molecular Basis for the Therapeutic Modulation of Hemoglobin Switching (E Bresnick et al.); Vertebrate Models for Sickle Cell Disease Research (B H Paw et al.); Stem Cell Biology (W Li & A W Flake); Bone Marrow Transplantation (R I Raphael & M C Walters); Genetically Engineered Cures: Gene Therapy for Sickle Cell Disease (P Malik & P Leboulch); Sickle Cell Disease: The Past, Present and Future Social and Ethical Dilemmas (V L Bonham, Jr. et al.); It Takes a Village to Cure Sickle Cell Disease (R Peterson & D Davis-Maye); Beyond National Borders: A Global Perspective on Advances in Sickle Cell Disease Research and Management, and New Challenges in the Genome Era (S F Ofori-Acquah & K Ohene-Frempong).
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