图书简介

1. Introduction; Part I. Clinical Issues: 2. The clinical diagnosis and misdiagnosis of Lewy body dementia; 3. The nosological status of Lewy body dementia; 4. Putative clinical and genetic antecedents of dementia associated with Parkinson?s disease; 5. Clinical features of patients with Alzheimer?s disease and Lewy bodies; 6. The nature of the cognitive decline in Lewy body dementia; 7. Non-cognitive symptoms in Lewy body dementia; 8. Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia; 9. Neuropsychological aspects of Lewy body dementia; 10. The neuroanatomical basis of cognitive deficits in Lewy body dementia; 11. The clinical and functional imaging characteristics of Parkinsonian-dementia; 12. Positron emission tomography findings in Parkinson?s disease and Lewy body dementia; 13. Clinical features of diffuse Lewy body disease in the elderly: analysis of 12 cases; 14. Senile dementia of Lewy body type - clinical features and prevalence in neuropathological postmortems; 15. Lewy body dementia in clinical practice; resume of clinical workshop sessions; Part II. Pathological Issues: 16. Pathological significance of Lewy bodies in dementia; 17. Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies; 18. What is the neuropathological basis of dementia associated with Lewy bodies?; 19. Cytoskeletal and Alzheimer-type pathology in Lewy body disease; 20. Diffuse Lewy body disease within the spectrum of Lewy body disease; 21. Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson?s disease and senile dementia of Alzheimer type; 22. Pathological and clinical features of Parkinson?s disease with and without dementia; 23. Dementia with Lewy bodies: relationship to Parkinson?s and Alzheimer?s diseases; 24. What do Lewy bodies tell us about dementia and Parkinsonism?; 25. Pathogenesis of the Lewy body; 26. Altered tau processing: its role in development of dementia in Alzheimer?s disease and Lewy body disease; 27. Cytoskeletal pathology in Alzheimer?s disease and Lewy body dementia - an epiphenomenon?; 28. Genetic correlations in Lewy body disease; resume of pathological workshop sessions; Part III. Treatment Issues: 29. Psychopharmacology of cognitive impairment in Parkinson?s disease; 30. Management of the non-cognitive symptoms of Lewy body dementia; 31. Altered consciousness and transmitter signalling in Lewy body dementia; 32. Cholinergic therapy and Lewy body dementia; 33. Clinical heterogeneity in dementia; responders to cholinergic therapy; 34. Tacrine and symptomatic treatment in Lewy body dementia; 35. Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms; 36. Neurotrophins and the cholinergic system in dementia; 37. Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinson?s disease; Resume of treatment workshop Sessions; Appendix.

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