RNA-Seq in Drug Discovery and Development

图书简介

The research and development process in modern drug discovery and development is a complex and challenging task. Using traditional biological test methods such as PCR to measure the expression levels or function of these genes is costly and time-consuming. RNA-seq can measure the expression patterns of thousands of genes simultaneously and provide insights into functional pathways or regulations in biological processes, which has revolutionized the way biological scientists examine gene functions. This book addresses the various aspects of the RNA-seq technique, especially its application in drug discovery and development.Features• One of the few books that focuses on the applications of the RNA-seq technique in drug discovery and development.• Comprehensive and timely publication which relates RNA sequencing to drug targets, mechanisms of action, and resistance.• The editor has extensive experience in the field of computational medicinal chemistry, computational biophysics, and bioinformatics.• Chapter authors are at the frontline of the academic and industrial science in this particular area of RNA sequencing.

Preface.................................................................................................................vii Editors................................................................................................................... ix Contributors.......................................................................................................... xi Chapter 1 Introduction to RNA Sequencing and Quality Control.................... 1 Robert Morris and Feng Cheng Chapter 2 Read Alignment and Transcriptome Assembly............................. 35 Robert Morris and Feng Cheng Chapter 3 Normalization and Downstream Analyses.................................... 61 Robert Morris and Feng Cheng Chapter 4 Constitutive and Alternative Splicing Events................................101 Robert Morris and Feng Cheng Chapter 5 The Role of Transcriptomics in Identifying Fusion Genes and Chimeric RNAs in Cancer.................................................... 129 Robert Morris, Valeria Zuluaga, and Feng Cheng Chapter 6 MiRNA and RNA-seq.................................................................. 153 Robert Morris and Feng Cheng Chapter 7 Toxicogenomics and RNA-seq......................................................171 Robert Morris, Kyle Eckhoff, Rebecca Polsky, and Feng Cheng Chapter 8 Herbal Medicine and RNA-seq.................................................... 205 Robert Morris and Feng Cheng Chapter 9 Single-Cell RNA Sequencing...................................................... 233 Robert Morris and Feng Cheng Index.................................................................................................................. 26

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RNA-Seq in Drug Discovery and Development（Drugs and the Pharmaceutical Sciences） 药物发现与开发中的RNA序列 药理学

RNA-Seq in Drug Discovery and Development（Drugs and the Pharmaceutical Sciences）

药物发现与开发中的RNA序列
药理学