A Closer Look at Polyadenylation(Biochemistry Research Trends)

仔细研究聚腺苷酸化

医学遗传学

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作      者
出  版 社
出版时间
2019年04月05日
装      帧
平装
ISBN
9781536153552
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页      码
213
语      种
英文
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图书简介
In response to various environmental cues and cellular stress, cells need to modify their protein expression pattern for proper cell functioning. The cell experiences diverse cellular stress as oxidative, genotoxic, and etc. The damage of the genome by certain chemicals or agents affects the cell integrity and leads to genotoxic stress. As such, this compilation discusses how different cellular stresses affect the polyadenylation process and modulate the polyadenylation machinery.Cytoplasmic polyadenylation plays an important role in oocyte maturation, mitotic cell cycle progression, cellular senescence and synaptic plasticity. Poly(a) tails can be elongated post-transcriptionally by noncanonical poly(a) polymerases, which can impact cells with limited transcriptional activity.A recent study is discussed wherein it is shown that that alternative cleavage and polyadenylation isoform expression influences about 10% of targeting by mirnas between any two cell types analysed and, more importantly, that the accuracy of target prediction can be improved if the cellular alternative cleavage and polyadenylation profile is considered.
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