图书简介
Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.
Section I: Reproductive tract development and gametogenesis 1. Developmental genetics of the male reproductive system Marisol O’Neill, Victor A. Ruthig, Meade Haller, Boryana Zhelyazkova, Jeffrey T. White, Nannan Thirumavalavan, and Dolores J. Lamb 2. Developmental genetics of the female reproductive tract Jessica Garcia de Paredes, Michael Strug, Jordan Gosnell, Marcos Cordoba, and Jose M. Teixeira 3. Genetics and genomics of early gonad development Fanghong Ou, Zhangting Wang, Jinyue Liao, Hoi-Ching Suen, Kai Kei Miu, and Wai-Yee Chan 4. Effects of aging on sperm chromatin Heather E. Fice and Bernard Robaire 5. In vitro spermatogenesis from pluripotent stem cells Jin Du, Qing-Qin Gao, Cheng Huang, Hai-Ping Jiang, Mo-Yu Dai, Yu-Fei Li, Jun Wu, and Qi Zhou 6. The molecular genetics of oogenesis Fan Zhai, Xinyi Ma, Liying Yan, and Jie Qiao 7. Growth of the mammalian oocyte: Focus on intercellular contact and communication Hugh J. Clarke 8. In vitro activation of ovarian follicles Kazuhiro Kawamura Section II: Embryo implantation, placenta development and pregnancy 9. Interaction of sperm and embryo with the female reproductive tract Yin Lau Lee, Andy Chun Hang Chen, and William Shu Biu Yeung 10. MicroRNAs in gametes and preimplantation embryos: Clinical implications Allison Tscherner, Nicholas Werry, Leanne Stalker, and Jonathan LaMarre 11. Epigenetic modifications in the human placenta Wendy P. Robinson, Maria S. Pen~ aherrera, Chaini Konwar, Victor Yuan, and Samantha L. Wilson 12. In vitro models of human blastocysts and early embryogenesis Jia Ping Tan, Xiaodong Liu, and Jose M. Polo 13. microRNAs in pregnancy: Implications for basic research and clinical management Peng Xu, Xuan Shao, Ming Liu, and Yan-Ling Wang 14. Human X-chromosome inactivation: Complexity and clinical implications Maria Jose Navarro-Cobos, Karanveer Bhangu, and Carolyn J. Brown 15. The intergenerational effects on fetal programming He-Feng Huang, Guo-Lian Ding, Xin-Yuan Li, Xin-Mei Liu, and Zi-Ru Jiang Section III: Infertility and assisted reproductive technology 16. Theoretical and experimental strategies for preservation and restoration of male fertility Ali Honaramooz 17. Update on the genetics and genomics of premature ovarian insufficiency Elena J. Tucker, Sylvie Jaillard, and Andrew H. Sinclair 18. Premature ovarian insufficiency Yingying Qin, Ting Guo, Shidou Zhao, and Zi-Jiang Chen 19. Genetics of polycystic ovary syndrome Tristan Hardy, Alice P. Rogers, and Robert J. Norman 20. Developmental origins and genetic basis of polycystic ovary syndrome T.M. Barber and S. Franks 21. Genetic basis of metabolism and inflammation in PCOS Yanli Pang, Yue Zhao, and Jie Qiao 22. Genetics and genomics of recurrent pregnancy loss Laura Kasak, Kristiina Rull, and Maris Laan 23. Genetics and genomics of endometriosis Linda C. Giudice, Richard O. Burney, Christian M. Becker, Stacey A. Missmer, Grant Montgomery, Nilufer Rahmioglu, Peter A.W. Rogers, and Krina Zondervan 24. Human genetics and assisted reproduction in endometriosis Ya-Ching Chou, Chien-Wen Chen, Endah Rahmawati, Guan-Lin Lai, Yun-Yi Ma, Yi-Xuan Lee, Ming-Jer Chen, and Chii-Ruey Tzeng 25. Uterus transplantation as an infertility treatment Mats Brannstrom, Ali Khatibi, Ghada Hussein, and Pernilla Dahm-KEUROahler 26. Impacts of COVID-19 on reproductive health and prenatal genetics Peng Yuan, Zhiqiang Yan, Wei Wang, Yao Li, Qilong He, Fan Zhai, Liying Yan, and Jie Qiao Section IV: Preimplantation/prenatal genetic diagnosis and screening 27. Genomics in reproductive medicine: Current and future applications Maurizio Poli and Antonio Capalbo 28. Molecular cytogenomics of human genetic disorders Zirui Dong, Kwong Wai Choy, and Cynthia C. Morton 29. Next-generation sequencing for gene panels, clinical exome, and whole-genome analysis Matthew A. Shanahan, Liesbeth Vossaert, and Ignatia B. Van den Veyver 30. Chromosomal microarrays and next-generation sequencing for diagnosis of fetal abnormalities Brynn Levy, Melissa Stosic, Jessica Giordano, Ronald Wapner, and Vimla Aggarwal 31. Noninvasive prenatal testing for genetic diseases Stephanie C.Y. Yu, Jason C.H. Tsang, and Y.M. Dennis Lo 32. Noninvasive prenatal testing/screening by circulating cell-free DNA Margot van Riel, Kate Stanley, and Joris R. Vermeesch 33. Application of new technologies in embryos: From gene editing to synthetic embryos M. Martin-Inaraja, I. Romayor, L. Herrera, N. Montserrat, and C. Eguizabal
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