Syncytia: Origin, Structure, and Functions

图书简介

This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development.The book covers the following topics:germline syncytia, evolution, function and structure;syncytia in embryogenesis and development;the role of somatic cell fusion in fungi, specialized somatic tissues, host defense and adaptation;syncytia induced by viruses and parasites;syncytia and circulating hybrid cells in cancer and other pathological conditions; It also discusses how the genomic adaptations of microorganisms to extreme habitats can prompt the evolution of mononuclear and multinucleate/syncytial cells.The book offers a fresh outlook on syncytia’s role in various processes: embryogenesis, organogenesis, adaptation, host defense, and development of specialized tissues. It highlights the importance of syncytia under physiological and pathological conditions.

Part I. Germline Syncytia, Evolution, Function, and Structure.- Chapter 1. The Ancient Origin and Function of Germline Cysts.- Chapter 2. Female Germline Cysts in Animals: Evolution and Function.- Chapter 3. Germline and Somatic Cell Syncytia in Insects.- Part II. Syncytia in Embryogenesis and Development.- Chapter 4. Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.- Chapter 5. Cell-Mediated Branch Fusion in the Drosophila Trachea.- Chapter 6. Trophoblast Syncytialization: A Metabolic Crossroads.- Chapter 7. Early Syncytialization of the Ovine Placenta Revisited.- Chapter 8. Syncytia in Utricularia: Origin and Structure.- Part III. Fungal and Somatic Cell Syncytia and Genomic View of Extremophiles as the Ancestral Precursors of Eukaryotic Syncytia.- Chapter 9. Syncytial Assembly-Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.- Chapter 10. Ancestors in The Extreme: A Genomics View of Microbial Diversity in Hypersaline Aquatic Environments.- Chapter 11. Somatic Cell Fusion in Host Defense and Adaptation.- Chapter 12. Osteoclasts at Bone Remodeling: Order from Order.- Chapter 13. Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle.- Part IV. Virus- and Parasite- Induced Syncytia.- Chapter 14. Virus-induced Cell Fusion and Syncytia Formation.- Chapter 15. HIV-1 Induced Cell-to-Cell Fusion or Syncytium Formation.- Chapter 16. Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion after Endocytosis in the HIV and SARS-Cov-2 Infections.- Chapter 17. Mathematical Modeling of Virus-Mediated Syncytia Formation: Past Successes and Future Directions.- Chapter 18. Syncytium Induced by Plant-parasitic Nematodes.- Part V. Cell Fusion and Syncytia in Cancer.- Chapter 19. Mechanisms of Cell Fusion in Cancer.- Chapter 20. Cell Fusion and Syncytia Formation in Cancer.- Chapter 21. The Hallmarks of Circulating Hybrid Cells.

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Syncytia: Origin, Structure, and Functions（Results and Problems in Cell Differentiation） 合胞体：起源、结构与功能 细胞生物学

Syncytia: Origin, Structure, and Functions（Results and Problems in Cell Differentiation）

合胞体：起源、结构与功能
细胞生物学