图书简介
Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds. This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.
Part I - Fundamentals of Inflammasome Biology 1. Overview of inflammatory processes at cellular level 2. Inflammasome formation and triggers 3. Cellular signaling, molecular activation and regulation of the NLRP1 inflammasome 4. Cellular signaling, molecular activation and regulation of the NLRP3 inflammasome 5. Cellular signaling, molecular activation and regulation of the NLRP6 inflammasome 6. Cellular signaling, molecular activation and regulation of the NLRC4 inflammasome 7. Cellular signaling, molecular activation and regulation of the AIM2 inflammasome 8. Cellular signaling, molecular activation and regulation of the Pyrin inflammasome 9. Cellular signaling, molecular activation and regulation of the non-canonical inflammasome 10. Cellular signaling, molecular activation and regulation of auto-active inflammasomes 11. Autophagy and the inflammasome 12. Inflammasome effector functions 13. Inflammatory caspases 14. Structural aspects of inflammasomes 15. Evolutive aspects of inflammasomes Part II - inflammasome role in disease processes 16. The inflammasome in cardiovascular diseases 17. Inflammasome implications in metabolic disorders 18. Inflammasome in venous thromboembolic disorders 19. Inflammasomes and neurodegenerative diseases 20. Inflammasome implication in diseases of the respiratory system 21. Inflammasomes and their regulation in oral disease 22. Inflammasomes in inflammatory bowel disease pathogenesis 23. Inflammasome induced inflammation and fibrosis in liver 24. Inflammasomes in sepsis 25. The Inflammasome in viral, bacterial and fungal infections 26. Autoinflammatory syndromes 27. The inflammasome in graft-versus-host disease 28. Implication of the inflammasomes in rheumatic diseases 29. The inflammasomes in kidney disease 30. Inflammasomes and cancer 31. Inflammasomes in the pathobiology of degenerative retinopathies. Part III - Inflammasome crosstalk in Cell Death 32. Regulation of pyroptosis by inflammasomes. 33. Crosstalk between necroptosis and inflammasome. 34. Apoptosis and inflammasome regulation 35. Implication of inflammasomes regulating different types of cell death 36. Regulation of neutrophil NETosis by inflammasomes Part IV - Therapeutic Opportunities 37. Therapeutic opportunities targeting the inflammasome 38. Development of selective inflammasome Inhibitors 39. Natural compounds blocking inflammasomes 40. Inhibitors targeting inflammasome effectors 41. Multi-inflammasome inhibitors
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