图书简介
Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.
Section 1: Alzheimer’s Disease and Dementias 1. Caenorhabditis elegans model of Alzheimer’s disease: applications to drug screening 2. APPswe/ PS1dE9 mouse model of Alzheimer’s disease: [18F]-florbetaben pet/ct imaging and beyond 3. Rat model of Alzheimer: applications to brain a-beta plaque accumulation Section 2: Amyotrophic Lateral Sclerosis 4. Murine modelling of familial amyotrophic lateral sclerosis, SOD1G86R: applications to ambroxol HCl 5. Rat Model of amyotrophic lateral sclerosis: SOD1G93A applications to mitochondria 6. Zebrafish model of amyotrophic lateral sclerosis: applications to oxidative stress studies in spinal motor neurons Section 3: Brain Injury 7. Murine models of traumatic brain injury and knock outs: investigations on hypocretin 8. Rat model of cortical impact traumatic brain injury: applications to studying neural stem cell grafts 9. Porcine modelling of traumatic brain injury: investigating agents such as valproic acid and beyond Section 4: Cerebral Palsy 10. Animal models of cerebral palsy: a new narrative 11. Rat model of cerebral palsy: applications to studying motor phenotype 12. Rabbit cerebral palsy modelling: applications to studying spinal hyper-excitability Section 5: Epilepsy 13. Murine modelling of epilepsy: applications to microRNA and hippocampus 14. Kainic acid-induced rat model of status epilepticus: A gamma-aminobutyric acid levels 15. Rats modelling of temporal lobe epilepsy: linking in cognition Section 6: Headaches and Migraines 16. A new narrative of genetic mouse models of migraine: features and applications 17. Rat model of headache with nitroglycerin: impact of auricular electrical stimulation 18. Nitroglycerin-induced migraine in mice: Nociceptin Opioid (NOP) receptors and beyond Section 7: Meningitis Rabbit tuberculous meningitis models: applications to neurosciences 19. Experimental pneumococcal meningitis: hippocampal DNA methylation 20. Pneumococcal meningitis modelling in mice Section 8: Multiple Sclerosis Biological models in multiple sclerosis: a new overview and narrative 21. The mouse model of multiple sclerosis : use of Artemisia dracunculus L. 22. Comparing models of multiple sclerosis: applications to biomarkers Section 9: Neuroinflammation Modelling neuroinflammation: CXCR2 signalling and myelin repair 23. Lipopolysaccharide- model of neuroinflammation: astrogliosis, microglial activation and beyond 24. Rat model of neuroinflammation: positron emission tomography (PET) tracer for imaging of P2X7 receptors Section 10: Neurotoxins Animal models in the neurotoxicology of the neurotoxin 2,4-D 25. Toluene as a model neurotoxin in mouse models 1-11-2019 26. Rat model of alcohol-related brain damage: application to thiamine deficiency and cytokines Section 11: Parkinson’s Disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine( MPTP)-induced mouse model of Parkinson’s disease: impact of Valeriana officinalis 27. alpha-synuclein BAC transgenic mice model of Parkinson’s disease: the sublaterodorsal tegmental nucleus and beyond 28. Rat model of parkinsonism: the nigro-vagal pathway Section 12: Peripheral Neuropathy Non-mammalian animal models of peripheral neuropathy 29. Mouse models of peripheral neuropathy: neurogenic molecule NSI-189 30. Rat model of cisplatin-induced peripheral neuropathy: features and applications Section 13: Prenatal Related Injury Porcine model of intrauterine growth restriction: Applications to the study of the hippocampus 31. Ethanol as a neurotoxin in model primates for in vitro exposure: brain development and beyond 32. Prenatal malnutrition: linking in oxidative stress Section 14: Stroke Mouse model of ischemic stroke: PET tracers 33. Canine model of stroke: optimizing complex multimodal treatment 34. Porcine Ischemic Stroke and applications to neural stem cells
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