The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods inin vitro andin vivo drug combination assessments. However, despite these advances, no book has served as a single source of information for statistical methods in drug combination research, nor has there been any guidance for experimental strategies.Statistical Methods in Drug Combination Studies fills that gap, covering all aspects of drug combination research, from designingin vitro drug combination studies to analyzing clinical trial data. Featuring contributions from researchers in industry, academia, and regulatory agencies, this comprehensive reference:Describes statistical models used to characterize dose–response patterns of monotherapies and evaluate the combination drug synergyOffers guidance for estimating interaction indices and constructing their associated confidence intervals to assess drug interactionIntroduces a practical and innovative Bayesian approach to Phase I cancer trials, including actual trial examples to illustrate useExamines strategies in the fixed-dose combination therapy clinical development via case studies stemming from regulatory reviewsEvaluates computational tools and software packages used to apply novel statistical methods in combination drug developmentStatistical Methods in Drug Combination Studies provides researchers with a solid understanding of the available statistical methods and computational tools and how to apply them in drug combination studies. The book is equally useful for statisticians to become better equipped to deal with drug combination

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