Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases

图书简介

This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases.It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer’s, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment.This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.

Chapter 1. Peroxisome: metabolic functions and biogenesis.- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk.- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration.- Chapter 4. Peroxisome biogenesis disorders.- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders.- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation.- Chapter 7. Heimler Syndrome.- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease.- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency.- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders.- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy.- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation.- Chapter 13. Biological functions of plasmalogens.- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.

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Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases（Advances in Experimental Medicine and Biology） 过氧化物酶体生物学：实验模型、过氧化物酶体疾病与神经系统疾病 细胞生物学

Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases（Advances in Experimental Medicine and Biology）

过氧化物酶体生物学：实验模型、过氧化物酶体疾病与神经系统疾病
细胞生物学