The book presents the confluence of wearable and wireless inertial sensor systems, such as a smartphone for deep brain stimulation for treating movement disorders, such as essential tremor, and machine learning. The machine learning distinguishes between distinct deep brain stimulation settings, such as ?On? and ?Off?status. This achievement demonstrates preliminary insight with respect to the concept of Network Centric Therapy, which essentially represents the Internet of Things for healthcare and the biomedical industry, inclusive of wearable and wireless inertial sensor systems, machine learning, and access to cloud computing resources. Imperative to the realization of these objectives the organization of the software development process. Requirements and pseudo code are derived and software automation using Python for post-processing the inertial signal data to a feature set for machine learning is progressively developed. A perspective of machine learning in terms of a conceptual basis and operational overview is provides. Subsequently, an assortment of machine learning algorithms is evaluated based on quantification of a reach and grasp task for essential tremor using a smartphone as a wearable and wireless accelerometer system. Furthermore, these skills regarding the software development process and machine learning applications with wearable and wireless inertial sensor systems enable new and novel biomedical research only bounded by the reader?s creativity. Key Features ? This book enables the reader to conduct unique and substantive research, only bounded by their own creativity. The book covers the application of wearable and wireless inertial systems, such as a smartphone, for the quantification of a highly prevalent movement disorder (Essential tremor) ? Central to the application of machine learning, which is thoroughly discussed from an applied perspective, is the presented software development process using Python for post-processing the acquired inertial signal data ? However, the reader may apply these techniques for any human movement characteristics of their interest

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