Looking Inside the Disordered Brain

Looking Inside the Disordered Brain

精神紊乱的本质
医学生物化学

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￥ 1306.00

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优惠

平台大促低至8折优惠

发货周期：预计5-7周发货

作者

Hariri, Ahmad R.

出版社

Oxford University Press

出版时间

2015年01月13日

装帧

平装

ＩＳＢＮ

9780878939794

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页码

220

开本

254x203mm

语种

英文

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暂无评分

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图书简介

What are the brain circuits that not only keep us alive but also allow us to thrive in our complex world, and how do even subtle disturbances within these circuits lead to abnormal behavior? Using a combination of research strategies—including neuroimaging (particularly fMRI) and abnormal and clinical psychology. Looking Inside the Disordered Brain provides students with a working knowledge of our rapidly evolving understanding of the foundational brain circuits supporting human social, emotional, and cognitive behavior, and describes how disruptions within these circuits are associated with symptoms of common psychiatric disorders. It first establishes how specific anatomical circuits process signals we receive from our ever-changing internal and external environments to create order in our behavior. It then looks inside the disordered brain and maps specific symptoms onto dysfunction within these circuits. The textbook features three neuroanatomical circuits (corticolimbic; corticostriatal; corticohippocampal) and their principal behavioral correlates (recognition and reaction; motivation and action; memory and executive control), as well as the pathological expression of dysfunction within each circuit (including depression, anxiety, phobia, mania, addiction, aggression, and disintegration of thought). The author emphasizes the dimensional nature of psychopathology by mapping specific symptoms within a broad diagnostic category onto disorder of the circuitry under review. For example, in major depressive disorder the symptoms of anxiety are mapped onto corticolimbic circuit dysfunction, the symptoms of anhedonia onto corticostriatal circuit dysfunction, and the symptoms of emotion dysregulation onto corticohippocampal circuit dysfunction. This is an effective strategy for introducing students to the limitations of categorical/diagnostic classifications (e.g., DSM-5) and highlighting the importance of considering behavior on a continuum from normal to abnormal.

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Yale University Library

Chapter 1. Getting Inside and Getting Around Circuit concepts and approach BOLD basics Neuroanatomical planes and directional terms UNIT 1. THE CORTICOLIMBIC CIRCUIT FOR RECOGNITION AND REACTION Chapter 2. The Corticolimbic Circuit: Anatomy Circuit hub: Amygdala (basolateral complex, central nucleus, and intercalated cell masses) Interconnected circuitry: thalamus, sensory association cortex, hypothalamus, brainstem, substantia innominata (bed nucleus of the stria terminalis and nucleus basalis of meynert), insula, hippocampal formation, prefrontal cortex Basic information flow supporting recognition and reaction Chapter 3. The Corticolimbic Circuit: Order Fear learning: Conditioning, extinction, recall Faces and facial expressions: threat, ambiguity, uncertainty, novelty Anxiety Chapter 4. The Corticolimbic Circuit: Disorder Amygdala hyper/hypoactivity and circuit imbalance Exaggerated and dysregulated responses to threat Symptoms including depression, mania, anxiety, phobia, aggression, and abnormal social interactions UNIT 2. THE CORTICOSTRIATAL CIRCUIT FOR MOTIVATION AND ACTION Chapter 5. The Corticostriatal Circuit: Anatomy Circuit hub: Ventral striatum (nucleus accumbens) Interconnected circuitry: thalamus, amygdala, ventral pallidum, dorsal striatum, dorsal pallidum, prefrontal cortex, midbrain (substantia nigra and ventral tegmental area) Basic information flow supporting motivation and action Chapter 6. The Corticostriatal Circuit: Order Reward learning: classical and instrumental conditioning Goal-directed behavior Primary and secondary reinforcers Impulsivity Chapter 7. The Corticostriatal Circuit: Disorder Ventral striatum hyper/hypoactivity and circuit imbalance Abnormal and dysregulated motivations and goal-directed behaviors Symptoms including anhedonia, mania, hyperactivity, aggression, addiction, body image distortion, overeating UNIT 3. THE CORTICOHIPPOCAMPAL CIRCUIT FOR MEMORY AND EXECUTIVE CONTROL Chapter 8. The Corticohippocampal Circuit: Anatomy Circuit hub: Dorsolateral prefrontal cortex Interconnected circuitry: Hippocampal formation (hippocampus, entorhinal cortex, perirhinal cortex, parahippocampal cortex), neocortical association areas, midbrain Basic information flow supporting memory and executive control Chapter 9. The Corticohippocampal Circuit: Order Long-term memory: The librarian and the library Executive control: Working memory, attention and response selection Focus and performance Chapter 10. The Corticohippocampal Circuit: Disorder Hippocampal formation dysfunction: deficits in encoding and recall of long-term memories Symptoms including retrograde and anterograde amnesia, mild cognitive impairment, and delusions Dorsolateral prefrontal cortex dysfunction: dysregulation of other circuits, disorganized thinking, remembering, and planning Symptoms including poor emotion regulation, impulse control, inattention, obsessions and compulsions, and disintegration of thought and executive control Glossary

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