图书简介
This book discusses recent advances in the field of translational stroke research. The editors have designed the book to爌rovide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and燾linicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.
Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.
Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak爄s an internationally recognized expert燾onducting translational燿rug development research for ischemic and hemorrhagic stroke.燑br/>
Dr. John H. Zhang is Professor爋f Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr.燴hang爄s an internationally recognized expert working on drug development for hemorrhagic stroke.
Stroke- Neuroprotection, Repair & Regeneration- The Continuum of Care.-營nterdisciplinary advances and potential of stem cell-based therapies for ischemic stroke.-燬tem cell transplants in the aged stroke brain: microenvironment factors.-燤odulating endogenous adult neural stem cells to improve regeneration in stroke brain.-燤obilization of endogenous neural stem cells to promote regeneration after stroke.-燭ranscriptional and genomic advances on the pathophysiology of stem cell repairment after hemorrhagic stroke.-燤odulation of post-stroke plasticity and regeneration by stem cell therapy and exogenic factors.-燬tem Cell-Paved Biobridge: A Merger of Exogenous and Endogenous Stem Cells toward Regenerative Medicine in Stroke.-燤ultiStem and other plastic adherence cells and their effect on immunomodulation and stroke recovery.-燙ombined stem cell and GCSF therapy for stroke.-燤arrow Stromal Cell Neurorestorative therapy of stroke.-燙ombination treatment of MSCs and Angelica sinensis? 爁or ischemic stroke.-燝ene and cell therapy and cell therapy for motor and cognitive recovery after stroke.-燬B623 Preclinical and Clinical Trial Experience.-燩reparing for Future Stem Cell Clinical Trials.-燛xosomes For Stroke.-燛xosome and MiRNA in Stroke.-營ntegrating Molecular, Cellular, and Systems Approaches to Repairing the Brain after Stroke.-燫egeneration of Neural Network after Stroke.-燛xtracellular matrix protein in subarachnoid hemorrhage-induced early brain injury.-燫ole of Proteases in Post-stroke brain damage and repair.-燭he NLRP3 inflammasome: 燼 possible therapeutic target for treatment of Stroke.-燤icroglial function in intracerebral hemorrhage injury and recovery.-燭he role of T Cells in post-stroke regeneration.-燭he inflammatory response and its effect on rehabilitation-induced repair processes after stroke.-燙omplement C3a- Shaping the plasticity of the post-stroke brain.
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