Epigenetics, Nuclear Organization & Gene Function:With implications of epigenetic regulation and genetic architecture for human development and health

图书简介

Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.

Part I; An introduction to epigenetics and epigenetic regulation; 1 Epigenetic phenomena in fungi, plants and animals; 2 The basic structure of chromatin; 3 The basic mechanism of gene transcription; Part II; Transcription is regulated by epigenetic mechanisms; 4 Chromatin modifications and remodeling; 5 Epigenetic chromatin changes and the transcription cycle; 6 The role of non-coding RNAs; 7 Maintenance of the active and inactive states; 8 DNA methylation and gene expression; 9 Regulation of domains and whole chromosomes; Part III; The interplay between transcription and nuclear structure; 10 Architectural organization of the genome; 11 The nuclear envelope; 12 The nucleolus; 13 Nuclear bodies; Part IV; Inheritance of chromatin structure and functional states; 14 Chromosome replication and genomic stability; 15 DNA repair and genomic stability; 16 Inheritance of chromatin modifications through the cell cycle; 17 Stem cells; 18 Nuclear reprogramming and induced pluripotency; 19 Transgenerational inheritance of epigenetic traits; Part V; Epigenetics, human health and development; 20 Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres; 21 Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling; 22 Developmental systems and their dysfunction

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Epigenetics, Nuclear Organization & Gene Function:With implications of epigenetic regulation and genetic architecture for human development and health 表观遗传学、核组织与基因功能：表观遗传调控和遗传结构对人类发育和健康的影响 遗传学

Epigenetics, Nuclear Organization & Gene Function:With implications of epigenetic regulation and genetic architecture for human development and health

表观遗传学、核组织与基因功能：表观遗传调控和遗传结构对人类发育和健康的影响
遗传学