Alzheimer’s Disease:Methods and Protocols

图书简介

Alzheimer’s disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer’s disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer’s Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer’s disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer’s d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.

to Alzheimer’s Disease.- The Genetics of Alzheimer’s Disease.- Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer’s Disease.- Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPP?).- Quantifying A?1–40 and A?1–42 Using Sandwich-ELISA.- Electrophoretic Separation and Immunoblotting of A?1–40 and A?1–42.- A?-Induced Proinflammatory Cytokine Release from Differentiated Human THP-1 Monocytes.- Effects of the ?-Amyloid Peptide on Membrane Ion Permeability.- Analysis of ?-Amyloid Peptide Degradation In Vitro.- Posttranslational Modifications of Amyloid Precursor Protein.- Posttranslational Modifications of the Amyloid Precursor Protein.- Using an Amyloid Precursor Protein (APP) Reporter to Characterize ?-Secretase.- Inhibition of ?-Secretase by Zinc Metalloproteinase Inhibitors.- Development of Neoepitope Antibodies Against the ?-Secretase Cleavage Site in the Amyloid Precursor Protein.- ?-Secretase.- Using ?-Secretase Inhibitors to Distiguish the Generation of the A? Peptides Terminating at Val-40 and Ala-42.- Designing Animal Models of Alzheimer’s Disease with Amyloid Precursor Protein (APP) Transgenes.- Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins.- Determining the Transmembrane Topology of the Presenilins.- Normal Proteolytic Processing of the Presenilins.- Apoptotic Proteolytic Cleavage of the Presenilins by Caspases.- The Phosphorylation of Presenilin Proteins.- Interaction of the Presenilins with the Amyloid Precursor Protein (APP).- Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains.- Characterization and Use of Monoclonal Antibodies to Tau and Paired Helical Filament Tau.- Tau Phosphorylation Both In Vitro and in Cells.- Transglutaminase-Catalyzed Formation of Alzheimer-Like Insoluble Complexes from Recombinant Tau.

Trade Policy 买家须知

关于产品：
● 正版保障：本网站隶属于中国国际图书贸易集团公司，确保所有图书都是100%正版。
● 环保纸张：进口图书大多使用的都是环保轻型张，颜色偏黄，重量比较轻。
● 毛边版：即书翻页的地方，故意做成了参差不齐的样子，一般为精装版，更具收藏价值。
关于退换货：
由于预订产品的特殊性，采购订单正式发订后，买方不得无故取消全部或部分产品的订购。
由于进口图书的特殊性，发生以下情况的，请直接拒收货物，由快递返回：
● 外包装破损/发错货/少发货/图书外观破损/图书配件不全（例如：光盘等）
并请在工作日通过电话400-008-1110联系我们。
签收后，如发生以下情况，请在签收后的5个工作日内联系客服办理退换货：
● 缺页/错页/错印/脱线
关于发货时间：
一般情况下：
●【现货】下单后48小时内由北京（库房）发出快递。
●【预订】【预售】下单后国外发货，到货时间预计5-8周左右，店铺默认中通快递，如需顺丰快递邮费到付。
● 需要开具发票的客户，发货时间可能在上述基础上再延后1-2个工作日（紧急发票需求，请联系010-68433105/3213）；
● 如遇其他特殊原因，对发货时间有影响的，我们会第一时间在网站公告，敬请留意。
关于到货时间：
由于进口图书入境入库后，都是委托第三方快递发货，所以我们只能保证在规定时间内发出，但无法为您保证确切的到货时间。
● 主要城市一般2-4天
● 偏远地区一般4-7天
关于接听咨询电话的时间：
010-68433105/3213正常接听咨询电话的时间为：周一至周五上午8：30～下午5：00，周六、日及法定节假日休息，将无法接听来电，敬请谅解。
其它时间您也可以通过邮件联系我们：customer@readgo.cn,工作日会优先处理。
关于快递：
● 已付款订单：主要由中通、宅急送负责派送，订单进度查询请拨打010-68433105/3213。

Alzheimer’s Disease:Methods and Protocols（Methods in Molecular Medicine） 精神病学

Alzheimer’s Disease:Methods and Protocols（Methods in Molecular Medicine）
精神病学