The Biological Basis of Schizophrenia

图书简介

For years lip service has been paid to a belief in a biological basis for schizophrenia, but ,nevertheless psychosocial and psychodynamic ?theories? of schizophrenia have been promulgated, and these have detracted from the all important biological work, Eclecticism has ruled the day and has caused considerable confusion, As a result research in schizophrenia has not progressed as fast as it should have done and treatment has been less effective than it could otherwise have been. This book is devoted to a wholly biological approach to the problem of schizophrenia, in the hope that many more workers will enter this exciting field of research. A wide variety of topics is covered, including brain structure; the genetics, pathogenesis and treatment of schizophrenia; a consideration of dietary and immunological factors and finally a chapter on alcoholism as it seems possible that the problems of schizophrenia and addiction are linked. We are grateful to all our contributors and to MTP Press for their enthusiasm for this book. Gwynneth P Hemmings William A Hemmings XI SECTION 1: Structure 1 The brain stem reticular formation K. E. WEBSTER There can be no question that the brain stem reticular lormation no longer exercises the same fascination for neurologists that it did a quarter of a century ago.

Section 1: Structure.- 1 The brain stem reticular formation.- Section 2: Genetics.- 2 Clinical and biochemical manifestations of acute intermittent porphyria: a working model for schizophrenia as an inborn error of metabolism.- Section 3: Pathogenesis.- 3 Psychoses from digestive origins.- 4 The amino hepato-entero-toxic theory of schizophrenia: an historical evaluation.- 5 Clues to the causation of schizophrenia.- 6 An evaluation of the dopamine hypothesis of schizophrenia.- 7 The dopamine hypothesis revisited.- 8 Tryptophan and serotonin in schizophrenia: a clue to biochemical defects?.- 9 Neurochemical findings in the post-mortem schizophrenic brain.- 10 The pineal gland: its possible significance in schizophrenia.- Section 4: Treatment.- 11 Rational drug treatment in schizophrenia.- 12 Investigations into serum folate and B12 concentrations in psychiatric in-patients with particular reference to schizophrenia.- 13 Propranolol and schizophrenia: objective evidence of efficacy.- Section 5: Dietary Factors.- 14 The effect of diet on brain neurotransmitters.- 15 Schizophrenia: Are some food-derived polypeptides pathogenic? Coeliac disease as a model.- 16 Some insights into the pathogenesis of schizophrenia.- 17 Nutrition and schizophrenia: implications and problems.- 18 The cytotoxic properties of wheat proteins.- 19 5-Hydroxytryptamine metabolism in coeliac disease.- 20 A preliminary investigation of dietary constituents and amphetamine-induced abnormal behaviour.- Section 6: Immunological Factors.- 21 Immunobiological approaches to the study of gut function.- 22 Nutrition and immunity: possible new approaches to research in schizophrenia.- 23 The absorption of large breakdown products of dietary proteins into the body tissues including brain.- 24 Antibodies to gliadin in serum of normals, coeliac patients and schizophrenics.- Section 7: Alcoholism.- 25 Screening tests for alcoholism.

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The Biological Basis of Schizophrenia 精神病学

The Biological Basis of Schizophrenia
精神病学