图书简介
On the occasion of the 450th anniversary of Philipp University, the porphyrin research group of. the Department of Clinical Biochemistry in the Faculty of Medicine organized an international symposium. This was held between June 28 and July 1, 1977, under the joint chairman ship of Professor Samuel Schwartz and the editor. The organizers and chairmen of the symposium wish to thank the Sozialminister of Hessen, Armin Clauss, the President of the German Society for Clinical Chemis try, Professor A. Delbrlick, and the Dean of the Faculty of Medicine of Philipp University, Professor F. Neurath, for their support and patronage. We are also grateful to Professor A. Treibs of the Institute of Organic Chemistry, Technical University of Munich. Professor Treibs, a former pupil, co-worker and now successor to the Nobel laureate Hans Fischer, kindly accepted the honorary presidency of this international symposium. The opening ceremony was inaugurated by the chairmen, with welcoming speeches by the President of Philipps University, Mr. Rudolf Zingel and patrons of the university. The editor outlined the 10 years of development of clinical biochemistry at Philipp University and traced in detail the continual development of its chief research effort in porphyria. It was pointed out that following the first international symposium on the regulation of porphyrin and heme biosynthesis in 1973 at Marburg (Doss, M. (ed. ): Regulation of Porphyrin and Heme Biosyn thesis.
Session I Pathobiochemistry of Heme Metabolism.- Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias.- Differential Patterns of Heme and Porphyrin Biosynthesis in Liver and Kidney: Metal Ion Blockade of ?-Aminolevulinate Synthase Introduction by Porphyrinogenic Agents.- The Regulatory Function of the Mitochondrial Inner Membrane in the Overall Ferrochelatase Reaction.- Permissive Effects of Hormone on the Induction of ?-Aminolevulinic Acid Synthase (ALA-S) in Cultured Chick-Embryo Liver Cells.- Session II Pathogenesis and Differential Diagnosis of Acute Hepatic Porphyrias.- Biochemical and Clinical Transitions Between the Hereditary Hepatic Porphyrias: New Concepts.- A New Approach to Porphyrias.- The Clinical Chemistry of Variegate Porphyria With Special Reference to the Identification of a New Plasma-Marker Porphyrin.- Expression of the Gene Defects of Acute Intermittent Porphyria (AIP) and Erythropoietic Protoporphyria (EPP) in Mitogen-Stimulated Lymphocytes.- Uroporphyrinogen-Synthase (URO-S) in Erythrocytes in Acute Intermittent Porphyria (AIP).- Hereditary Coproporphyria: Demonstration of a Genetic Defect in Coproporphyrinogen Metabolism.- Session III Clinical Course and Therapy of Acute Hepatic Porphyrias.- A Case of Acute Intermittent Porphyria, Relapsing Acute Pancreatitis, and Unconjugated Hyperbilirubinemia (Gilbert’s Syndrome).- Acute Intermittent Porphyria: EEG Changes and Their Relationship to the Biochemical Manifestation.- Family Studies of Patients With Acute Intermittent Porphyria (AIP): Neurological, Biochemical, and Genetic Investigations.- The Effect of Hematin in “ Inducible” Hepatic Porphyria.- Therapy of Acute Intermittent Porphyria With Ovulation Inhibitors in Women.- Session IV Pathogenesis, Clinical Biochemistry, and Treatment of Chronic Hepatic Porphyrias.- Clinical Observation, Diagnostics, and Therapy for Symptomatic and Hereditary Porphyria Cutanea Tarda.- Uroporphyrinogen Decarboxylase (URO-D) Defect in Erythrocytes in Chronic Hepatic Porphyrias.- The Problem of Possible Etiological Factors in the Origin and Development of PCT.- Incidence of Porphyria in Slovenia.- Chronic Hepatic Porphyrias and the Role of Iron in These Disorders.- Chloroquine in the Treatment of Porphyria Cutanea Tarda.- Chloroquine Treatment of Porphyria Cutanea Tarda.- Clinical Importance of Suburoporphyrins.- Current Diagnostic Problems in the Cutaneous Porphyrias in Infancy. Presentation of Unusual Cases.- Session V Porphyria and Environment.- Influence of Environmental Factors on Porphyrin Metabolism.- Porphyrinogenic Action of Polyhalogenated Aromatic Compounds, With Special Reference to Porphyria and Environmental Impact.- Lead Poisoning Attributable to Automobile Traffic.- Neoplasms and Metabolic Disturbances of Porphyrins in Rats With Chronic Experimental Lead Poisoning.- Session VI Diagnosis of Lead Intoxication.- Time Course and Compartment Relations of Heme-Synthesis Disturbances Induced by Inorganic Lead Compounds in Humans.- Urinary Porphyrin Profiles in Acute Lead Poisoning: Relation to Differentiation From Acute Intermittent Porphyria.- Determination of Lead and Cadmium in Whole Blood by Electrothermal Atomic Absorption Spectroscopy.- Biochemical Behavior of ?-Aminolevulinic Acid Dehydratase During Chronic Oral Lead Poisoning in Sheep.- Diagnostic Criteria of Increased Lead Absorption in Occupational Medicine.- Analysis of the Diagnostically Relevant Heme Precursors (5-Aminolevulinic Acid, Coproporphyrin, and Protoporphyrin) in Lead Poisoning by Use of Thin-Layer Chromatography.- Comparison of Fluorometric Micromethods for Analyzing Erythrocytic Porphyrins (EP).- Session VII Therapy of Lead Intoxication.- Therapy for Lead Poisoning.- Subclinical Effects of a Ubiquitous Poison: Lead.- Correlations Between Chronic Exposure to Lead and Exc
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