Enzyme Kinetics in Drug Metabolism:Fundamentals and Applications

图书简介

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.

Enzyme Kinetics in Drug Metabolism ? Fundamentals and Applications.- Fundaments of Enzyme Kinetics.- Different Enzyme Kinetic Models.- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance.- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions.- Multi-Enzyme Kinetics and Sequential Metabolism.- Consideration of the Unbound Drug Concentration in Enzyme Kinetics.- Enzyme Kinetics of Oxidative Metabolism ? Cytochromes P450.- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase.- Enzyme Kinetics of Conjugative Enzymes ? PAPS.- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs).- Principles and Experimental Considerations for in vitro Transporter Interaction Assays.- Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data ? from in vitro Tools to Mechanistic Modeling.- The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers.- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism.- Variability in Human in vitro Enzyme Kinetics.- Sources of Interindividual Variability.- Case Study 1. Practical Considerations with Experimental Design and Interpretation.- Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies.- Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies ? Real Life Examples.- Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast.- Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development.- Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes.- Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors? Experiences.

Trade Policy 买家须知

关于产品：
● 正版保障：本网站隶属于中国国际图书贸易集团公司，确保所有图书都是100%正版。
● 环保纸张：进口图书大多使用的都是环保轻型张，颜色偏黄，重量比较轻。
● 毛边版：即书翻页的地方，故意做成了参差不齐的样子，一般为精装版，更具收藏价值。
关于退换货：
由于预订产品的特殊性，采购订单正式发订后，买方不得无故取消全部或部分产品的订购。
由于进口图书的特殊性，发生以下情况的，请直接拒收货物，由快递返回：
● 外包装破损/发错货/少发货/图书外观破损/图书配件不全（例如：光盘等）
并请在工作日通过电话400-008-1110联系我们。
签收后，如发生以下情况，请在签收后的5个工作日内联系客服办理退换货：
● 缺页/错页/错印/脱线
关于发货时间：
一般情况下：
●【现货】下单后48小时内由北京（库房）发出快递。
●【预订】【预售】下单后国外发货，到货时间预计5-8周左右，店铺默认中通快递，如需顺丰快递邮费到付。
● 需要开具发票的客户，发货时间可能在上述基础上再延后1-2个工作日（紧急发票需求，请联系010-68433105/3213）；
● 如遇其他特殊原因，对发货时间有影响的，我们会第一时间在网站公告，敬请留意。
关于到货时间：
由于进口图书入境入库后，都是委托第三方快递发货，所以我们只能保证在规定时间内发出，但无法为您保证确切的到货时间。
● 主要城市一般2-4天
● 偏远地区一般4-7天
关于接听咨询电话的时间：
010-68433105/3213正常接听咨询电话的时间为：周一至周五上午8：30～下午5：00，周六、日及法定节假日休息，将无法接听来电，敬请谅解。
其它时间您也可以通过邮件联系我们：customer@readgo.cn,工作日会优先处理。
关于快递：
● 已付款订单：主要由中通、宅急送负责派送，订单进度查询请拨打010-68433105/3213。

Enzyme Kinetics in Drug Metabolism:Fundamentals and Applications（Methods in Molecular Biology） 药理学

Enzyme Kinetics in Drug Metabolism:Fundamentals and Applications（Methods in Molecular Biology）
药理学