Theoretical and Computational Methods in Genome Research

医学遗传学

原   价:
1419.00
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1135.00
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作      者
出  版 社
出版时间
2012年11月05日
装      帧
平装
ISBN
9781461377085
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页      码
330
开      本
10.00 x 7.00 x 0.72
语      种
英文
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图书简介
The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transcends boundaries tradi­ tionally separating genetics, biology, mathematics, physics, and computer science. Com­ puters have, of course, been intensively used in the field of life sciences for many years, even before genome research started, to store and analyze DNA or protein sequences; to explore and model the three-dimensional structure, the dynamics, and the function of biopolymers; to compute genetic linkage or evolutionary processes; and more. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function ofgenomes ofhigher organisms, has generated, how­ ever, not only a huge and exponentially increasing body of data but also a new class of scientific questions. The nature and complexity of these questions will also require, be­ yond establishing a new kind ofalliance between experimental and theoretical disciplines, the development of new generations both in computer software and hardware technolo­ gies. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can attack with suc­ cess. Many of us still feel that computational models rationalizing experimental findings in genome research fulfill their promises more slowly than desired. There is also an uncer­ tainty concerning the real position of a ’theoretical genome research’ in the network of established disciplines integrating their efforts in this field.
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