Apoptosis and Cancer:Methods and Protocols

Apoptosis and Cancer:Methods and Protocols（Methods in Molecular Biology）

细胞凋亡与癌：方法与协议
医学生物化学

原价：

￥ 1651.25

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优惠

平台大促低至8折优惠

发货周期：外国库房发货，通常付款后3-5周到货

作者

Gil Mor, Yale University School of Medicine, New Haven, CT, USA; Ayesha Alvero, Yale University School of Medicine, New Haven, CT, USA

出版社

Humana Press

出版时间

2007年10月11日

装帧

精装

ＩＳＢＮ

9781588294579

复制

页码

266

开本

语种

英文

综合评分

暂无评分

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图书简介

Our understanding of the apoptotic pathway and its regulation has improved significantly in the last 10 years. However, as our knowledge of the intricate intracellular events increase, we realize the complexity of the regulatory mechanisms that control it. As such, Apoptosis and Cancer describes the performance of contemporary techniques for studying the biology of apoptosis and its role in cancer. This book is a collaboration between academics- and industry-based scientists. The chapters have the technical development characteristic of an academic environment and the standardized system necessary for translating a product to general use, as provided by the industry. Thus, the protocols described within this groundbreaking new volume will aid both an academic laboratory interested in further characterizing the mechanism of apoptosis and an industry laboratory interested on identifying new target molecules or screening for new compounds with potential clinical use. The authors – all leaders in the field – have created a comprehensive text that covers the newest available techniques as well as conventional basic techniques. Apoptosis and Cancer will undoubtedly provide the necessary resources to everyone interested in the area of apoptosis.

Preface.- Contributors.- Modulation of Apoptosis to Reverse ChemoresistanceGil Mor, Michele K. Montagna, and Ayesha B. Alvero.- Caspase-3 Activation is a Critical Determinant of Genotoxic Stress-Induced ApoptosisSuparna Mazumder, Dragos Plesca, and Alexandru Almasan.- Flow Cytometry Enumeration of Apoptotic Cancer Cells by Apoptotic RateDavid Diaz, Alfredo Prieto, Eduardo Reyes, Hugo Barcenilla, Jorge Monserrat, and Melchor Alvarez-Mon.- Detection of Cancer-Related Proteins in Fresh-Frozen Ovarian Cancer Samples Using Laser Capture MicrodissectionDan-Arin Silasi, Ayesha B. Alvero, Jechiel Mor, Rui Chen, Han-Hsuan Fu, Michele K. Montagna, and Gil Mor.- Flow Cytometric Detection of Activated Caspase-3Richard Fox and Martine Aubert.- The ChemoFx™ Assay: An Ex Vivo Chemosensitivity and Resistance Assay for Predicting Patient Response to Cancer ChemotherapyStacey L. Brower, Jeffrey E. Fensterer, and Jason E. Bush.- Correlation of Caspase Activity and In Vitro Chemo-Response in Epithelial Ovarian Cancer Cell LinesAyesha B. Alvero, Michele K. Montagna, and Gil Mor.- Assessing Expression of Apoptotic Markers Using Large Cohort Tissue MicroarraysElah Pick, Mary M. McCarthy, and Harriet M. Kluger.- Mitochondria Potential, Bax “Activation,” and Programmed Cell DeathC. Michael Knudson and Nicholas M. Brown.- In Vitro and In Vivo Apoptosis Detection Using Membrane Permeant Fluorescent-Labeled Inhibitors of CaspasesBrian W. Lee, Michael R. Olin, Gary L. Johnson, and Robert J. Griffin.- Caspase Activity AssaysAndrew L. Niles, Richard A. Moravec, and Terry L. Riss.- Multiplex Caspase Activity and Cytotoxicity AssaysAndrew L. Niles, Richard A. Moravec, and Terry L. Riss.- Homogeneous, Bioluminescent Proteasome AssaysMartha A. O’Brien, Richard A. Moravec, Terry L. Riss, and Robert F. Bulleit.- A Simple Method for Profiling miRNA ExpressionJia-Wang Wang and Jin Q. Cheng.- Apoptotic Caspase Activation and ActivityJean-Bernard Denault and Guy S. Salvesen.- Biochemical Analysis of the Native TRAIL Death-Inducing Signaling ComplexHenning Walczak and Tobias L. Haas.- Laser Microdissection Sample Preparation for RNA AnalysesChristopher J. Vega.

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