Inflammation and Cancer:Methods and Protocols: Volume 2, Molecular Analysis and Pathways

Inflammation and Cancer:Methods and Protocols: Volume 2, Molecular Analysis and Pathways（Methods in Molecular Biology）
肿瘤学

原价：

￥ 1941.25

售价：

优惠

平台大促低至8折优惠

发货周期：外国库房发货，通常付款后3-5周到货

作者

Serguei V. Kozlov, National Cancer Institute Center for Advanced Preclinical Research, Frederick, MD, USA

出版社

Humana Press

出版时间

2010年11月19日

装帧

平装

ＩＳＢＮ

9781617379055

复制

页码

408

开本

语种

英文

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暂无评分

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According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.

Crossroads of Inflammation and Cancer: Molecular Aspects.- Immunohistochemical Analysis of 8-Nitroguanine, A Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis.- Molecular Analysis of Genetic Instability Caused by Chronic Inflammation.- Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways.- Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-?B.- Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome.- cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures.- Analysis of the TLR/NF-?B Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation.- Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue.- Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery In Inflammation-Related Oncogenesis.- Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-cancer Drug Candidates in a High-Throughput Format.- The NF-?B Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-?B Activity.- Inhibiting Proinflammatory NF-?B Signaling Using Cell-Penetrating NEMO Binding Domain Peptides.- Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients.- Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis.- Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis.- Inflammation and Tumor Progression: A Lesson from TNF-?-Dependent FAK Signaling in Cholangiocarcinoma.- Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPAR? ? 14-3-3? Pathway.- PPAR?/? Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells.- Investigating Macrophage and Malignant Cell Interactions In Vitro.- Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy.- Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer.- Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer.- Peptide YY Mediates Inhibition of Tumor Growth and Inflammation.

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