图书简介
This is the first textbook devoted entirely to understanding and treating necrotizing enterocolitis (NEC), one of the leading causes of death and disability in premature infants. NEC continues to occur in neonatal units across the world, and the overall mortality has remained stubbornly high since its first description decades ago. Despite significant research into NEC, and a greater understanding of its underlying causes, there is no single source of information to which the care team can turn for guidance. This book fills that important gap in clinical care.
In selecting the topics for this inaugural textbook, three guiding principles have been followed. First, to include chapters that provide detailed information for the medical team – the doctors and nurses, the therapists and pharmacists, the chaplains and the child life workers – so that each team member can optimally recognize, prevent and treat patients with this disease. Second, to ensure that chapters cover the depth and breadth of the latest clinical and scientific research into NEC, each selected to identify specific preventative strategies or therapies for this disease. Third, and perhaps most importantly, to focus not only on the child with NEC, but also on the child’s family, in order to provide comprehensive information about a disease that families have barely heard about, until the jarring day when their precious infant is affected by it.
This book therefore:
serves as a "how-to guide" for the care of the infant with NEC
summarises critical new research and offers guidelines for future key research areas
addresses the complex and difficult issues surrounding care of the critically ill infant suffering from NEC
Written for the entire health care team including paediatric surgeons, neonatologists, developmental paediatricians, epidemiologists, ethicists, child life professionals, therapists
List of contributors 1. Introduction: Necrotizing Enterocolitis, Its Victims, and the Journey Ahead David J. Hackam 2. Nursing Considerations in Necrotizing Enterocolitis: Management of Infant Stomas Margaret Birdsong, and Michelle Felix 3. Nursing Considerations in Necrotizing Enterocolitis: Management of Central Venous Catheters Margaret Birdsong, and Michelle Felix 4. An Updated Overview of the Medical Management of Necrotizing Enterocolitis Lila S. Nolan, Martin Goree, and Misty Good 5. Clinical Clues, Biochemical Indices, and Biomarkers: Diagnostic Considerations in Necrotizing Enterocolitis Karl G. Sylvester, and Enrico Danzer 6. Imaging Considerations in NEC Diagnosis: Plain Films, Ultrasound, and Everything else Emily A. Dunn 7. Spontaneous Intestinal Perforation (SIP) is not Necrotizing Enterocolitis (NEC) but Remains the Major Confounder of NEC Data Phillip V. Gordon, Jonathan R. Swanson, and Reese H. Clark 8. International Practice Patterns in NEC Management: North America, Europe, and Australasia Maarten Janssen Lok, Carlos Zozaya, Sinobol Chusilp, and Agostino Pierro 9. Feeding Strategies in the Patient with Necrotizing Enterocolitis Krista E. Cooksey, Olivia B. Parks, Angela N. Lewis, and Misty Good 10. Surgery for Necrotizing Enterocolitis: Indications, Techniques, and Outcomes David Hackam 11. Major Issues Related to Progress in NEC Josef Neu 12. Probiotics in the Prevention of Necrotizing Enterocolitis Mark A. Underwood 13. Cardiovascular, Hemodynamic, and Critical Care Considerations in the Patient with Necrotizing Enterocolitis Christine M. Cortelyou, Zachary A. Vesoulis, and Misty Good 14. Neurodevelopmental Considerations in the Patient with Necrotizing Enterocolitis Panagiotis Kratimenos, and Frances J. Northington 15. Lung Disease and Ventilator Strategies in Necrotizing Enterocolitis Jegen Kandasamy, and Namasivayam Ambalavanan 16. Clinical Trials in NEC Research: Advances, Perils, and Pitfalls Cheryl Battersby, Chris Gale, and Neena Modi 17. Management of Short Bowel Syndrome after Necrotizing Enterocolitis Ross Beckman, and Samuel Alaish 18. Necrotizing Enterocolitis in Unusual Cases: Term Infants, Congenital Anomalies, and Comorbidities Spencer W. Beasley 19. Intestinal Transplantation for Necrotizing Enterocolitis Geoffrey Bond 20. Optical Spectroscopy for the Detection of Necrotizing Enterocolitis Seth D. Goldstein 21. Anesthetic Management of the Neonate with Necrotizing Enterocolitis John J. McCloskey 22. Novel and Alternative Techniques in Surgery for Necrotizing Enterocolitis Maame Efua S. Sampah, and David J. Hackam 23. Supporting NEC Risk Awareness with Bedside Tools like GutCheckNEC Sheila M. Gephart 24. Health Economics and Care Delivery Issues in Necrotizing Enterocolitis Meredith E. Mowitz, and John A.F. Zupancic 25. Quality Improvement and Necrotizing Enterocolitis Minesh Khashu, and Sunitha Vimalesvaran 26. Implementation strategies for Quality Improvement to avoid necrotizing enterocolitis Sheila M. Gephart 27. Clinical Outcomes in Children with NEC Mark D. Stringer 28. Contextualizing Necrotizing Enterocolitis within Health Disparities Research Amaris M. Keiser 29. Ethical Issues in the Care of Children with Necrotizing Enterocolitis Margaret R. Moon, and Renee D. Boss 30. Family Perspective of Necrotizing Enterocolitis Jennifer Canvasser 31. The Role of Toll-Like Receptor Signaling in the Pathogenesis of NEC Maame Efua Sampah, and David J. Hackam 32. The Role of Growth Factor Signaling in the Development and Treatment of Necrotizing Enterocolitis Rita D. Shelby, Terrence M. Rager, Barrett P. Cromeens, and Gail E. Besner 33. The Role of Platelet-Activating Factor in the Pathogenesis of Necrotizing Enterocolitis Michael Caplan 34. The Role of Vascular Development in the Pathogenesis of Necrotizing Enterocolitis Isabelle G. De Plaen, Elizabeth Managlia, and Xiaocai Yan 35. Bile Acids in the Pathogenesis of Necrotizing Enterocolitis Melissa Halpern 36. Bacterial Communities in the Pathogenesis of Necrotizing Enterocolitis Brigida Rusconi, Misty Good, and Barbara Warner 37. The Importance of Immune Cells in the Pathogenesis of NEC Andres Gonzalez Salazar, and David J. Hackam 38. The Role of Nitric Oxide Signaling in the Pathogenesis of Necrotizing Enterocolitis Anatoly Grishin, Patrick T. Delaplain, Jin Wang, Michael Mallicote, Michelle Nguyen, Michael Philippe-Auguste, Christopher P. Gayer, and Henri R. Ford 39. The Silver Lining: The Small Intestinal Epithelial Barrier and Its Role in Necrotizing Enterocolitis Mark R. Frey, Misty Good, and Steven J. McElroy 40. Innate and Adaptive Immune Dysfunction and Necrotizing Enterocolitis Paula Osterhout, Christina S. Kim, and Erika C. Claud 41. Intestinal Immune Adaptation and Necrotizing Enterocolitis Mathias W. Hornef 42. Advancements in Research on Necrotizing Enterocolitis Pathogenesis and Prevention Using Pigs Douglas Burrin, Juan Marini, Murali Premkumar, Barbara Stoll, and Per Torp Sangild 43. Small Animal Models for the Study of Necrotizing Enterocolitis and \"NEC in a Dish\" Mark L. Kovler, Chhinder P. Sodhi, and David J. Hackam 44. Nutritional Considerations in Necrotizing Enterocolitis Jae H. Kim 45. The Paneth Cell and Its Role in the Development of NEC Brian A. Juber, and Steven J. McElroy 46. Human Donor Milk and Necrotizing Enterocolitis Maggie Meeks, and Rachael Lamb 47. The Genetic Basis of NEC Susceptibility Lovya George, Wei Yu, Alain Cuna, and Venkatesh Sampath 48. Anemia as a Modifiable Risk Factor for NEC Ravi Mangal Patel 49. Lipids and Lipid Metabolism in Postnatal Gut Development and Risk of Intestinal Injury Camilia R. Martin 50. Machine Learning in Necrotizing Enterocolitis: Challenges and Opportunities Jennine Weller, and David J. Hackam 51. Necrotizing Enterocolitis Risk from a Maternal-Fetal Medicine Perspective Mark L. Kovler, Savannah Ireland, Angie C. Jelin, and Eric B. Jelin 52. Future Directions and Research Opportunities in NEC: The Top Ten Unanswered Questions and Top Five Areas of Research Focus David Hackam Index
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