METALLOTHIONEINS IN BIOCHEMISTRY AND PATHOLOGY

亲金属蛋白:生物化学与病理学

神经病学

原   价:
1698.00
售   价:
1273.00
发货周期:预计3-5周发货
作      者
出  版 社
出版时间
2008年10月22日
装      帧
精装
ISBN
9789812778932
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页      码
336
语      种
英文
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库存 30 本
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图书简介
Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments. This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer’s and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.
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