Total Chemical Synthesis of Proteins

图书简介

How to synthesize any native or modified protein in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins in the test tube. Comprehensive in scope, this important reference explores the three main ligation methods: native chemical ligation, sugar-assisted ligation, and ketoacid-hydroxylamine ligation. It includes information on synthetic strategies for various protein types, including glycoproteins, sulfoproteins, and membrane proteins. The most important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also provide insight on the challenges that remain to be unravelled. This unmatched resource: Contains valuable insights from the pioneers in the field of native chemical ligation Presents proven synthetic approaches for a wide range of different protein types Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Characterization of synthetic proteins Native chemical ligation N to S acyl shifts in protein synthesis Hydrazide-based protein synthesis Chemical ubiquitination Glycoprotein synthesis Expediting protein synthesis Synthesis of membrane proteins Sugar-assisted ligation in protein synthesis Protein semisynthesis Expanding native chemical ligation via novel amino acid derivatives Oxime ligation Synthesis of selenoproteins Purification-free ligations Controlling segment solubility in large protein synthesis Total chemical synthesis of proteins in neurodegenerative diseases Solid phase chemical ligation Auxiliaries in chemical protein synthesis Peptide ligations at sterically demanding sites Protein synthesis applied for backbone protein engineering Histone synthesis Cylic peptide and protein synthesis via ligation methods Synthesis of proteins with post-translational modification mimics Deciphering protein folding using chemical protein synthesis

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Total Chemical Synthesis of Proteins 化学史

Total Chemical Synthesis of Proteins
化学史