The Handbook of Pre-clinical Continuous Intravenous Infusion answers the needs of researchers and technicians involved with pharmacological testing by providing complete instructions in a single volume reference for a range of infusion techniques delivered to several species. It provides guidelines for the use of a variety of equipment including tail cuffs, implanted buttons, and mini-osmotic pumps; detailed information on surgical preparation and surgical suite design, and the proper use of anesthesia, analgesics, and antibiotics, as well as the humane handling of animal models. With contributions from several experts, this authoritative volume allows researchers to proceed with confidence in undertaking critical studies.


Also, you might be interested in a review of the book published in the British Toxicology Society Newsletter in 2000, which I append below.
Guy

"Continuous intravenous infusion using cannulated animals is still a relatively new technique for drug administration. To date, literature on the subject is scattered with no central publication. This situation is no longer the case with this excellent book. Handbook of Preclinical Continuous Intravenous Infusion introduces and describes in detail the methodology associated with this route of dose administration in the 6 most commonly used species in preclinical evaluation toxicity studies. Areas covered include surgical technique, study design within repeat and reproduction toxicity studies, advantages and disadvantages with the technique, suitable vehicles plus expected in-life and pathological findings. The welfare of the laboratory animal is frequently addressed which is important as this is a "stressful" technique. What is particularly good about this handbook is that it highlights the fact that continuous infusion is now a routine route of dose administration in many laboratories, for use to evaluate drugs to be given continuously in a clinical setting and/or to avoid ad

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