图书简介
This book has the ambition to gather, for the first time, chapters describing scientific computing and numerical modeling for a deeper understanding of mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties, skin barrier function, and homeostasis, covered through several chapters describing either biological or physical models at different scales.
Preface. Foreword. PART 1: Skin color. Multilayer Modeling of Skin Color and Translucency. Dermal component based optical modeling of the skin translucency: impact on the skin color. Mathematics and biological process of skin pigmentation. PART 2: Skin biomechanics. State-of-the-art constitutive models of skin biomechanics. Fiber-matrix models of the dermis. Cellular scale model of the stratum corneum. PART 3: Skin barrier. Mathematical models of skin permeability: microscopic transport models and their predictions. Cellular scale modelling of the skin barrier. Molecular scale modeling of skin permeation. Accessing the molecular organization of the stratum corneum using high resolution electron microscopy and computer simulation. PART 4: Skin fluids and components. Water diffusion through stratum corneum. Accurate multi-scale skin model suitable for determining the sensitivity and specificity of changes of skin components. Model based Quantification of Skin Microcirculatory Perfusion. PART 5: Skin homeostasis. Graphical Multi-Scale Modeling of Epidermal Homeostasis with EPISIM. Heuristic Modeling Applied to Epidermal Homeostasis.
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