图书简介
Managing Patient Health in the Genomic Era: Family Health History and Adult Disease Risk presents strategies on the practical integration of genomic technologies in conducting accurate family health histories to improve patient management, enhance adult disease risk assessment, provide more precise diagnosis, and support effective interventions and treatment. In more than fourteen evidence-based chapters, the book examines family health history’s place in genomic medicine, FHH tools and strategies, how to identify existing and novel genetic markers, how to identify lineage specific variants within families, how to find effective interventions based on genetic testing, gene-environment interactions, FHH social networking, data sharing, and more. Readers will discover succinct commentary and key examples to assist with their local needs. Relevant principles of genetic biology and inheritance are both explored in-depth, with guidance on available support networks and online resources also provided.
1. Genomic Medicine Overview Part I. FHH, Genomics, and Disease Risk 2. Family Health History’s Place in Genomic Medicine 3. FHH as a driver of genetic testing 4. FHH contextualizes genetic test results 5. FHH help to identify existing and new genetic markers 6. Lineage specific variants: principles and detection (Brian Shirts, U. Washington) 7. FHH, gene-environment interactions 8. Finding Effective Interventions in the Genomic era 9. Tools for FHH collection and Analysis 10. Applying algorithms, Epidemiology, Evidence-based intervention (Beth Hauser) 11. Genetic counseling: description and purpose (Adam Buchanan) 12. Closing the loop: patient followup Part III. Primary Care in the Genomic Era 13. Prognosis for FHH-social networking for extended families, consent issues 14. Conclusion: The future: whole genome sequencing, familial variant database, gene editing
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