Chemical Exchange Saturation Transfer Imaging:Advances and Applications

图书简介

Chemical Exchange Saturation Transfer is a powerful Magnetic Resonance Imaging (MRI) contrast mechanism with unique features. This is the first authoritative textbook covering all aspects of CEST imaging. The rapid expansion that CEST imaging has seen over the past 16 years since the seminal Ward and Balaban paper in 2000 has created a need for a graduate-level handbook that describes the wide assortment of issues that come in to play when trying to apply CEST imaging to medicine.

On the discovery of the \"saturation transfer\" method. Development of Chemical Exchange Saturation Transfer (CEST). History of in vivo Exchange Transfer spectroscopy and imaging at Johns Hopkins University and Kennedy Krieger Institute. Early discover and investigations of paraCEST agents in Dallas. The birth of CEST agents in Torino. General theory of CEST image acquisition and post-processing. Uniform-MT- method to separate CEST contrast from MT effects. hyperCEST imaging. The current landscape of diaCEST imaging agents. The evolution of genetically encoded CEST MRI reporters: opportunities and challenges. paraCEST agents: design, discovery and implementation. Transition metal paraCEST probes: alternatives to lanthanides. Responsive paraCEST MRI contrast agents and their biomedical applications. Saturating compartmentalized water protons: Liposome- and Cell-based CEST agents. Principles and applications of Amide Proton Transfer (APT) imaging. Cartilage and intravertebral disc imaging and the Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) experiment. glucoCEST: imaging glucose in tumors. Creatine Chemical Exchange Saturation Transfer imaging. Iodinated contrast media as pH responsive CEST agents.

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Chemical Exchange Saturation Transfer Imaging:Advances and Applications 化学交换饱和转移成像 化学工程基础学科

Chemical Exchange Saturation Transfer Imaging:Advances and Applications

化学交换饱和转移成像
化学工程基础学科