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Preface; Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera; 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker; 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel; Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar; 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarz?bek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida; 6. Development of the brain and metabolism David Patterson; Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone; 8. Early medical caretaking and follow-up Alberto Rasore-Quartino; 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte; Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack; 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks; 12. Memory development and learning Stefano Vicari and Deny Menghini; 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal; 14. Speech perception, stimulation and phonological development Michele Pettinato; 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki; 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales; Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera; Conclusions; Index.

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