The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets.
Key selling features:
Describes developing cell/biomaterial constructs for regenerative medicine
Reviews state-of-the-art of biomaterial carriers
Summarizes the unique problems associated with key tissue and organ targets
Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models
Biomaterials. Natural biomaterials for cell delivery. Synthetic biomaterials for cell delivery. Decellularized tissues as vehicles for cell delivery. In vivo cell delivery. Biomaterials for angiogenesis. Void filling and bulking. Pancreatic Islet transplantation. Cartilage and bone. Cardiac tissue. In vitro cell conditioning within biomaterials. Skeletal muscle. Tendons and ligaments. Heart valve. Cardiac tissue. Blood vessels. Perspectives for clinical translation. GMP and quality control in biomaterial scaffolds. Host response: vascularization, innervation, remodeling. Non-destructive imaging. Selection of animal models.