Drug Delivery Across Physiological Barriers

图书简介

For most therapeutics, the targets of action are intracellular and/or require penetration across cellular and tissue layers. The design of strategies capable of controlling the transport of therapeutic agents through these physiological barriers has, hence, become an imperative and yet challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field from multiple perspectives, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

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Harvard Library

Introduction. Physiological Barriers Controlling Penetration and Transport of Substances in the Body. Structure and function of epithelial and endothelial barriers. The plasma membrane as a semipermeable barrier. Biology and regulation of protein sorting and vesicular transport. Pathogens and intracellular transport. Strategies for Drug Penetration across Tissue Compartments. Drug transport across the skin. Mucosal barriers. Transport of therapeutics across the gastrointestinal epithelium. Crossing the endothelial barrier. Nanoparticle-based drug delivery to solid tumors. Drug Transport into Cells and Subsequent Intracellular Trafficking. Membrane lipids and drug transport. Drug delivery systems that fuse with the plasmalemma. Endocytosis and the endolysosomal route in drug delivery. Endo-lysosomal escape. Intracellular transport to the mitochondria and other organelles.

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Drug Delivery Across Physiological Barriers 跨生理屏障的药物传递 制药工程

Drug Delivery Across Physiological Barriers

跨生理屏障的药物传递
制药工程