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Acknowledgements; Introduction; 1: Personalized Medicine; What is personalized medicine?; What personal factors impact your health?; 2: Genome Fundamentals; What is DNA?; What is a genome?; What does the genome do?; How does one person’s genome differ from another person’s genome?; How do genomes of men and women differ?; How is the genome decoded?; 3: An Introduction to Cancer Genetics; What is cancer and how does it arise?; How do the BRCA1 and BRCA2 genes cause cancer?; What are examples of other genes implicated in cancer?; How does genetic information help us treat cancer?; 4: Genomics and Cancer Treatment; What has been learned from genome sequencing of cancer?; How can genome sequencing advance cancer treatment?; If I have cancer should I get my tumor genome sequenced?; Why do anticancer drugs fail and how might genomic approaches help address this issue?; Can genetics and genomics help detect early cancer and monitor treatment effectiveness?; A new approach: What is immunotherapy?; How can genomics be used to harness the patient’s own immune system to fight their cancer?; 5: Solving Mystery Diseases; What is a mystery genetic disease?; How many Mendelian diseases are there?; How are genes responsible for genetic disorders identified?; How useful are genomic approaches to solving mystery genetic diseases?; Why can’t most Mendelian diseases be solved?; 6: Complex genetic diseases; What is a complex genetic disease?; How do complex genetics affect neurological diseases?; How does complex genetics affect metabolic diseases?; Can some diseases be both monogenic and complex?; 7: Pharmacogenomics; How can your genome directly help guide drug treatments for treating disease?; What are other ways your DNA can guide drug treatments; Are there sex differences in drug effects?; 8: Genomics for the Healthy Person; How can getting your genome sequence improve your health?; Can genome sequencing affect the drugs someone take?; Can genetic testing be used to predict sports performance and injuries?; Will sequencing my genome affect my children and my relatives?; 9: Prenatal Testing; How are genome sequencing technologies changing prenatal testing?; Can genome sequencing be used to identify other mutations, beyond chromosomal abnormalities, that might cause disease?; Can genetic testing be useful for choosing healthier embryos and producing designer babies?; 10: Effects of the environment on the genome and epigenetics; How does the environment contribute to health?; When did people first begin to study environmental effects?; When do environmental effects begin?; Can environmental factors directly impact the genome?; What is epigenetics?; What are some examples of environmental effects on physiology that are mediated through epigenetics?; What is the role of epigenetics in disease?; How will increased understanding of epigenetics impact health care?; 11: Other ’Omes; What other ’omes are useful for medicine?; How can the transcriptome and proteome be useful?; How can the metabolome be useful?; How deeply can a person be analyzed?; 12: The personal microbiome; What is the microbiome?; How is the microbiome studied?; How does the microbiome affect health?; How does diet affect the microbiome?; Can the microbiome affect other aspects of our lives?; Can the microbiome be altered to improve human health?; 13: Your Immune System and Infectious Diseases; How does your immune system protect you?; How does the immune system vary among people and affect our health?; How can we analyze infectious diseases?; 14: How does age affect your health?; Are there genetic factors underlying longevity?; Are there environmental factors that affect aging and longevity?; Does epigenetics control aging?; Will we someday be able to control our aging?; 15: Wearable Health Devices; What other types of personal health information can be readily collected?; How will this information be made available to, and used by, the individual?; 16: Big Data and medicine; How much data can be gathered about a single person?; How much data can be gathered about a group of people?; How can a large database assist in medical care?; How can Big Data guide lifestyle decisions?; What are the opportunities for industry in Big Data Medicine?; 17: Delivery of genomic information; Who controls your genomic and other health information?; Who will deliver genomic information to you?; What is the role of the physician?; What are the implications of direct-to-consumer genomic testing?; 18: Ethics; Can your genetic information be used against you?; What are the concerns surrounding routine (or even mandated) genetic screening?; What is a possible solution?; 19: Education; Can we educate people to understand genomic information?; How do we educate physicians to understand genomic information; Who else should we educate? What is the role of health care providers, insurers and policy makers?; 20: Privacy: Identifying people from their sequences.; Can people be identified solely from the genome sequence?; Will getting my genome sequenced affect my family members?; 21: Paying for personalized medicine; Who pays for genome sequencing in treating disease?; Who pays for genome sequencing in preventive medicine?; Will genome sequencing make health care cheaper?; Will people act on genomic information?; 22: The future of personalized medicine; What other technologies will be prevalent in the personalized medicine space?; What will the future look like?; Index

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