图书简介

1. Psychopathology 101; a. Mental status examination; b. The nature of psychiatric symptoms: insights from behavioral neurology; c. Cognitive symptoms: psychotic and non-psychotic thinking; d. Disturbances in the form of thought; e. Disturbances in emotions; f. Disturbances in motivation: the role of salience and personality; g. Disturbances in memory; h. Points to remember; 2. Depression and Dementia: An Introduction to Systems Neuroscience and Psychiatry; a. Some basic concepts about systems neuroscience & psychiatry; b. Depression; c. Dementias; i. Dementia of the Alzheimer’s type (DAT); ii. Behavioral variant frontotemporal dementia (bvFTD); d. Points to remember; 3. Systems Neuroscience & Psychiatry: Basic Principles; a. The brain is complex but not hopeless; b. Network theory and brain systems; c. Organization of the brain; d. Big picture principles of brain function; e. Basic principles of ICNs; f. Points to remember; 4. Brain Networks and the Human Mind; a. Cognition (Thinking); i. Working memory & prefrontal cortex (PFC); ii. How does the brain select thought content?; iii. PFC does more than working memory; iv. PFC and neuropsychiatric disorders; v. Perception is cognitively complex; vi. Lateralized brain function & cognition; vii. Intelligence and cognitive flexibility; b. Emotions: computing values & meaning; i. What values, what meaning?; ii. How are emotions processed?; iii. Other emotions & other brain regions; iv. What triggers emotional responses in the brain?; c. Motivation: the importance of having goals; i. How does motivation work?; ii. What determines our expectations?; d. Summary: a simplified overview of brain systems and mind; e. Points to remember; 5. Psychiatric Disorders and Brain Networks; a. Psychiatric disorders and defects in mental error correction; b. Why do individuals with psychiatric disorders fail to correct mental errors?; c. Rethinking psychiatric classification and endophenotypes; d. What do we know about ICNs and psychiatric disorders?; i. Cognitive disorders: psychosis; ii. Obsessive-compulsive disorder (OCD): cognitive or emotional disorder?; iii. Anxiety disorders as primary emotional disorders; iv. Emotional disorders: primary major depression; v. Motivational disorders: substance abuse; vi. Other abused drugs: hallucinogens; e. Summary: recurring themes; f. Points to remember; 6. The Hippocampus: Synapses, Circuits, and Networks; a. Why is the hippocampus important?; b. What is the hippocampus?; c. How does information flow within the hippocampal system?; d. What do hippocampal subregions do?; e. Synaptic plasticity: how the hippocampus learns; f. The hippocampus does not act alone; g. Sleep and the hippocampus; h. Neurogenesis (new neurons) and the hippocampus; i. Information flow: a reprise; j. Points to remember; 7. Network Dysfunction: Stress, Psychiatric Disorders and the Hippocampus; a. Psychiatric disorders and structural changes in the hippocampus; b. Causes of hippocampal changes in psychiatric illnesses; c. The stressed hippocampus: lessons from animal models; d. Recent human studies in mood and psychotic disorders; e. Can defects in connectivity be corrected? Potential therapeutic targets; f. What about other brain regions and networks?; g. Points to remember; 8. Genetics, Epigenetics, and Plasticity; a. Genetics and psychiatry; b. Epigenetics, the environment, and psychiatry; c. Stress, allostasis, and psychiatry; d. Molecules, networks, and treatments; e. Points to remember; 9. Conceptualizing causes of psychiatric disorders; a. Developmental abnormalities; b. Abnormalities of ICN connectivity that develop later in life; c. Abnormalities resulting from exogenous or endogenous substances; i. Exogenous substances; ii. Endogenous substances; d. Abnormalities resulting from traumatic brain injury; e. Abnormalities resulting from defects in brain metabolism; f. Abnormalities due to aging; g. Points to remember; 10. Neurotransmitters and Receptors; a. Neurotransmitters and receptors; i. The brain uses a variety of neurotransmitters; ii. Transmitters use a variety of receptors; b. Neurotransmitters and synapses: complex signaling devices; c. Transmitters, synapses, and brain rhythms; d. Why antidepressants take time to work while benzodiazepine anxiolytics act quickly; e. Points to remember; 11. Methods of Determining Diagnosis and Cause; a. Current methods of diagnosis; b. Current use of laboratory and imaging procedures; c. Current use of psychological testing; d. Future approaches to diagnosis; e. Future trends related to psychiatric diagnoses; f. Points to remember; 12. Why Do Some Psychiatric Disorders Become Chronic Problems?; a. Problems with current treatments and practice; b. Brain mechanisms contributing to refractory illnesses; c. Connectivity networks, brain mechanisms and refractory disorders; i. Anosognosia; ii. Anergia; iii. Amotivation; iv. Aplasticity; v. Asociality; d. How can psychiatry take advantage of synaptic plasticity?; i. The brain needs to learn; ii. The brain needs novelty; iii. Social interactions are important; iv. Lifestyle can have huge and non-linear effects on outcomes; e. Points to remember; 13. Approaches to Treatment; a. Psychopharmacology; i. Mechanisms of action; ii. Antidepressants; iii. Anxiolytics; iv. Antipsychotics; v. Mood stabilizers; vi. Anti-dementia agents; vii. Stimulants; viii. Drugs of abuse; b. Brain stimulation methods; i. Electroconvulsive therapy (ECT); ii. Vagus nerve stimulation (VNS); iii. Transcranial magnetic stimulation (TMS); iv. Deep brain stimulation (DBS); c. Psychotherapies; d. Lifestyle interventions; e. Rehabilitative versus etiologic therapies; f. The role of the patient and others in treatment; g. Points to remember; 14. The Future of Psychiatry; a. Psychiatry and clinical neuroscience; b. Psychiatric diagnosis and treatment; c. Psychiatry and rehabilitative medicine; d. Psychiatry and primary care; e. Psychiatry and public health; f. Training future psychiatrists; 15. Appendix; Index

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