Stimulant Drugs and ADHD:Basic and Clinical Neuroscience

图书简介

Stimulant drugs are widely used in the treatment of ADHD in children and adults, yet their mechanism of action have been poorly understood. This volume is the first to integrate advances in the basic and clinical neurosciences in order to shed new light on this important question. The chapter topics span basic research into the neuroanatomy, neurophysiology and neuropsychology of catecholamines, animal models of ADHD, and clinical studies of neuroimaging, genetics, pharmacokinetics and pharmacodynamics, and the cognitive pharmacology of stimulants. The result is a careful, comprehensive, and insightful synthesis by a group of well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research.

Part I: Phenomenology; 1: Mary V. Solanto: Attention-Deficit/Hyperactivity Disorder: Clinical Features; 2: Lawrence L. Greenhill: Clinical Psychopharmacology of Stimulant Medication in ADHD; Part II: Basic Neuroscience; Amy F.T. Arnsten: Introduction to Part II; 3: David A. Lewis: The Catecholamine Innervation of Primate Cerebral Cortex; 4: Jane R. Taylor & J. David Jentsch: Stimulant Effects on Striatal and Cortical Dopamine Systems Involved in Reward-Related Behavior and Impulsivity; 5: Anthony A. Grace: Psychostimulant Actions on Dopamine and Limbic System Function: Relevance to the Pathophysiology and Treatment of ADHD; 6: Craig W. Berridge: Arousal- and Attention-Related Actions of the Locus Coeruleus-Noradrenergic: Potential Involvement in the Therapeutic Actions of Amphetamine-Like Stimulants; 7: Amy F.T. Arnsten: Dopaminergic and Noradrenergic Influences on Cognitive Functions Mediated by Prefrontal Cortex; 8: Sherry A. Ferguson: A Review of Rodent Models of ADHD; 9: Terje Sagvolden: The Spontaneously Hypertensive Rat as a Model of ADHD; Part III: Clinical Neuroscience; Mary V. Solanto: Introduction to Part III; 10: F. Xavier Castellanos: Neuroimaging Studies of ADHD; 11: James Swanson & Nora Volkow: Pharmacokinetic and Pharmacodynamic Properties of methylphenidate in Humans; 12: Colin B. Denney and Mark Rapport: The Cognitive Pharmacology of Stimulants in Children with ADHD; 13: Mitul A Mehta, Barbara J. Sahakian, and Trevor W. Robbins: Comparative Psychopharmacology of Methylphenidate and Related Drugs in Human Volunteers, Patients w/ ADHD and Experimental Animals; 14: Steven R. Pliska: Comparing the Effects of Stimulant and Non-Stimulant Agents on Catecholamine Function: Implications fot Theories of ADHD; Part IV: Integration; 15: Mary V. Solanto, Amy F.T. Arnsten, and F. Xavier Castellanos: The Neuroscience of Stimulant Drug Action: Implications for ADHD; Appendix 1: Charles Bradley: The Behavior of Children Recieving Benzedrine

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Stimulant Drugs and ADHD:Basic and Clinical Neuroscience 精神病学

Stimulant Drugs and ADHD:Basic and Clinical Neuroscience
精神病学