The Epothilones: An Outstanding Family of Anti-Tumor Agents

有机化学

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1326.00
作      者
出  版 社
出版时间
2010年12月13日
装      帧
平装
ISBN
9783211999288
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页      码
260
语      种
英语
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Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives
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