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Contributors; Preface; Part I. Introduction to Modular Organization of the Networks of Gene Functions and Cancer: 1. Systems biology of cancer progression Sam Thiagalingam; 2. Lessons from cancer genome sequencing Antoine Ho and Jeremy S. Edwards; 3. Application of bioinformatics to analyze the expression of tissue-specific and housekeeping genes in cancer Xijin Ge; Part II. Alterations in the Regulatory Networks of Fundamental Cellular and Molecular Events in Cancer: 4. Events at DNA replication origins and genome stability Kathleen R. Nevis, Kimberly L. Raiford, Cyrus Vaziri and Jeanette Gowen Cook; 5. Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer Arnaud Krebs and László Tora; 6. Regulation and dysregulation of protein synthesis in cancer cells Michael J. Clemens, Androulla Elia and Simon J. Morley; Part III. Networks of Events Responsible for the Manifestation of Aberrant Genetic and Epigenetic Codes in Cancer: 7. Genomic instability and carcinogenesis Mark E. Burkard and Prasad V. Jallepalli; 8. Epigenomic code José Ignacio Martín-Subero and Manel Esteller; 9. MicroRNA epigenetic systems and cancer Holly Lewis and Aurora Esquela-Kerscher; 10. Dietary and environmental influences on the genomic and epigenomic codes in cancer Hamid Abdolmaleky and Jin-Rong Zhou; Part IV. Functional Networks of Events that Modulate Phenotypic Manifestation of Cancer: 11. Regulatory signaling networks in cell transformation and cancer Yashaswi Shrestha and William C. Hahn; 12. RAS signaling networks Douglas Faller; 13. The PI3K pathway in cancer Amancio Carnero; 14. TGFβ and BMP signaling in cancer Panagiotis Papageorgis, Arthur W. Lambert, Sait Ozturk and Sam Thiagalingam; 15. The Wnt signaling network in cancer Johanna Apfel, Jignesh R. Parikh, Patricia Reischmann, Rob M. Ewing, Oliver Müller, Yu Xia and Isabel Dominguez; 16. Apoptotic pathways and cancer Jian Yu and Lin Zhang; 17. Molecular links between inflammation and cancer Paola Allavena, Giovanni Germano and Alberto Mantovani; 18. Cancer metastasis Sait Ozturk, Arthur W. Lambert, Chen Khuan Wong, Panagiotis Papageorgis and Sam Thiagalingam; 19. Cancer metabolism Dimitrios Anastasiou, Jason W. Locasale and Matthew G. Vander Heiden; 20. Tumor microenvironment: blood vascular system in cancer metastasis Shantibhusan Senapati, Rakesh K. Singh and Surinder K. Batra; Part V. Current State of the Evolving MMMN Cancer Progression Models of Cancer: 21. Genetic alterations in glioblastoma multiforme Giselle Y. López, Marc Samsky, Rosanne Jones, Cory Adamson and Hai Yan; 22. Breast cancer Arthur W. Lambert, Sait Ozturk, Chen Khuan Wong, Panagiotis Papageorgis and Sam Thiagalingam; 23. The role of growth factor induced changes in cell fate in prostate cancer progression Min Yu, Gromoslaw A. Smolen, Daniel A. Haber and Shyamala Maheswaran; 24. Colon cancer Anthony Scott and Zhenghe Wang; 25. Biology of human stomach cancer Bryan G. Sauer and Steven M. Powell; 26. Pancreatic cancer Sergii Ivakhno, Kristopher Frese, Simon Tavare, Christine Iacobuzio-Donahue and David Tuveson; 27. Deregulated signaling networks in lung cancer Anurag Singh; 28. Modular signaling in hematopoietic malignancies Adam Lerner; Part VI. Applications of Comprehensive Cancer Progression Models in the Fight against Cancer: 29. Role of network biology and network medicine in early detection of cancer Asad Umar and Simon Rosenfeld; 30. Systems biology in cancer biomarkers for early detection, diagnosis and prognosis Sudhir Srivastava and Karl Krueger; 31. Prognosis of cancer Sharyn Katz and Wafik S. El-Deiry; 32. Cancer pharmacogenomics: challenges, promises, and its application to cancer drug discovery Lihua Yu and Kevin Webster; Index.

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