图书简介
This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.
PART I : OVERVIEW OF CNS DEVELOPMENT AND DISORDERS.- 1. Overview of CNS Organization and Development.- 2. Neural Induction and Regionalization.- 3. Neural Stem Cells, Differentiation, and Migration.- 4. Neurotrophins and Cell Death.- 5. Synaptogenesis.- 6. Axonal Guidance.- 7. Myelination.- 8. Epigenetics.- 9. The Impact of An Adverse Intrauterine Environment on Neurodevelopment.- 10. Stress as a Determinant of Neurodevelopmental Outcomes.- 11. Sex differences in Neurodevelopment and its Disorders.- PART II : AUTISM SPECTRUM DISORDERS.- 12. The History of Autism Spectrum Disorder.- 13. Epidemiology.- 14. An Approach to the Diagnosis of Autism Spectrum.- 15. Cognition.- 16. The Neuroradiology of Autism: Framing neuroimaging investigations of the autistic brain based on the US NIMH Research Domain Criteria.- 17. Neuropathology of Autism.- 18. Genetics and Epigenetics of ASD.- 19. Preclinical Models of Autism Spectrum Disorder.- 20. Biomedical Interventions for Autism Spectrum Disorder.- 21. Interventions in ASD – Psychosocial Interventions for ASD.- PART III : FETAL ALCOHOL SPECTRUM DISORDER.- 22. Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD.- 23. Epidemiology of alcohol consumption among pregnant and childbearing age women and Fetal Alcohol Spectrum Disorder.- 24. Diagnosis.- 25. Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorder (FASD).- 26. Neuropathological changes in humans with history of prenatal alcohol exposure or diagnosis of fetal alcohol spectrum disorder.- 27. Genetics and Epigenetics of FASD.- 28. Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research and Clinical Practice.- 29. Interventions.- PART IV : CEREBRAL PALSY.- 30. Clinical Vignettes.- 31. Epidemiology.- 32. Diagnosis.- 33. Neuroradiology Of Cerebral Palsy.- 34. Neuropathology Of “Cerebral Palsy”.- 35. Genetics and Genomics of Cerebral Palsy.- 36. Pre-Clinical Models of Cerebral Palsy.- 37. Therapeutic Approaches for the Treatment of Cerebral Palsy and Developmental Disability.- PART V : CO-MORBIDITIES IN NEURODEVELOPMENTAL DISORDERS.- 38. Sleep Disorders.- 39. Optimizing Therapy of Seizures in Children and Adolescents with Developmental Disabilities.- 40. Behavioral and Mental Health Disorders (including Attentional Disorders).- 41. Role of Gender and Neurodevelopmental Disabilities.- 42. A non‐categorical approach to childhood neurodisability: concepts, evidence and implications for clinical practice, organization of services, teaching, and research.- 43. Pain and Symptom Management in Neurodevelopmental Disorders: Sensory and Nociceptive Function/Pain and Symptom Management.- 44. Pharmacology, Psychopharmacology and Adverse Drug Reactions.- 45. Developmental origins, differential susceptibility and resilience in neurodevelopmental disorders.- PART VI : NEURODEVELOPOMENTAL DISORDERS IN THE CONTEXT OF FAMILIES.- 46. Children with Neurodevelopmental Disabilities and the Right to Health.- 47. Patient Navigation: Core Concepts and Relevance to the Field of Pediatric Neurodisability.- 48. Evaluating the Economic Impact of Neurodevelopmental Disability Intervention on the Family and Community.- PART VII : RESOURCES.- 49. Using Large-Scale Population-Based Data.- 50. Tools for Knowledge Dissemination and Translation to help your journey from research to impact.
Trade Policy 买家须知
- 关于产品:
- ● 正版保障:本网站隶属于中国国际图书贸易集团公司,确保所有图书都是100%正版。
- ● 环保纸张:进口图书大多使用的都是环保轻型张,颜色偏黄,重量比较轻。
- ● 毛边版:即书翻页的地方,故意做成了参差不齐的样子,一般为精装版,更具收藏价值。
关于退换货:
- 由于预订产品的特殊性,采购订单正式发订后,买方不得无故取消全部或部分产品的订购。
- 由于进口图书的特殊性,发生以下情况的,请直接拒收货物,由快递返回:
- ● 外包装破损/发错货/少发货/图书外观破损/图书配件不全(例如:光盘等)
并请在工作日通过电话400-008-1110联系我们。
- 签收后,如发生以下情况,请在签收后的5个工作日内联系客服办理退换货:
- ● 缺页/错页/错印/脱线
关于发货时间:
- 一般情况下:
- ●【现货】 下单后48小时内由北京(库房)发出快递。
- ●【预订】【预售】下单后国外发货,到货时间预计5-8周左右,店铺默认中通快递,如需顺丰快递邮费到付。
- ● 需要开具发票的客户,发货时间可能在上述基础上再延后1-2个工作日(紧急发票需求,请联系010-68433105/3213);
- ● 如遇其他特殊原因,对发货时间有影响的,我们会第一时间在网站公告,敬请留意。
关于到货时间:
- 由于进口图书入境入库后,都是委托第三方快递发货,所以我们只能保证在规定时间内发出,但无法为您保证确切的到货时间。
- ● 主要城市一般2-4天
- ● 偏远地区一般4-7天
关于接听咨询电话的时间:
- 010-68433105/3213正常接听咨询电话的时间为:周一至周五上午8:30~下午5:00,周六、日及法定节假日休息,将无法接听来电,敬请谅解。
- 其它时间您也可以通过邮件联系我们:customer@readgo.cn,工作日会优先处理。
关于快递:
- ● 已付款订单:主要由中通、宅急送负责派送,订单进度查询请拨打010-68433105/3213。
本书暂无推荐
本书暂无推荐