This book covers three main domains: (i) psychiatric pharmacotherapy for treatment of patients with “primary” psychiatric disorders and interventions adversely affecting the kidneys and medication adjustments due to comorbid kidney disease; (ii) interventions for complex and often multiple psychiatric comorbidity of chronic kidney disease and transplant patients; and (iii) mental health care for clinicians themselves involved in the care of patients with end-stage kidney disease, dialysis, and transplantation. Key features of the text include content-specific guidance, easy-to-reference advice, and illustrative clinical vignettes. The book focuses on pharmacological and non-pharmacological approaches of psychiatric syndromes that commonly occur in patients with kidney disease. These patients typically have multiple needs that differ among individuals based on the complexity of their illness, as well as caregiver supports and resources available to them. The coexistence of psychiatric syndromes in kidney disease patients who require specialized medical treatments represents a challenge to nephrologists regarding diagnosis and ongoing treatment. To overcome this, principles of psychotherapy and psychopharmacology are reviewed, with emphasis on organ impairment and drug-drug interactions specific to nephrology. The psychopharmacokinetics of medications used to treat patients with chronic kidney disease are discussed, which requires special consideration of the route of elimination, volume of distribution of the drug, hydrophilicity and drug protein binding; all are factors that affect the ability to dialyze a drug. This book also covers issues with medication nonadherence in patients with chronic kidney disease and psychiatric comorbidity, as well as the associated issues in dialysis and renal transplantation. Additionally, chapters cover various additional topics addressing an active stance towards health promotion in chronically ill patients, including the critical role of the diet and physical activity. Such advice is often complex and changing depending on the stage of chronic kidney disease and the individual needs of the patient. Written by specialists in the field, Psychonephrology: A Guide to Principles and Practice serves as a valuable reference and teaching tool that provides an opportunity for learning across a rapidly evolving medical field. Ultimately, the goal of this book is to lead to more regular conceptual focus on the term and the field beyond the clinical pragmatism, which also is emphasized.

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