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Contributors Preface PART I: INTRODUCTION AND OVERVIEW Chapter 1. Normal Hematopoiesis and Diagnosis Algorithms for Cytopenias and Cytoses Chapter 2. Familial/Inherited Mutations and Risks of Hematologic Malignancies Chapter 3. Hematopathology Diagnostic Techniques and Assays Chapter 4. Minimal Residual Disease Assays PART II: MYELOPROLIFERATIVE NEOPLASMS Chapter 5. Polycythemia Vera Chapter 6. Essential Thrombocythemia Chapter 7. Primary Myelofibrosis Chapter 8. Chronic Myelogenous Leukemia Chapter 9. Chronic Neutrophilic Leukemia Chapter 10. Systemic Mastocytosis Chapter 11. PDGFRA/PDGFRB/FGFR1 Myeloid Neoplasms PART III: MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES Chapter 12. Myelodysplastic Syndromes Chapter 13. Aplastic Anemia Chapter 14. Paroxysmal Nocturnal Hemoglobinuria PART IV: MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS Chapter 15. Myelodysplastic/Myeloproliferative Overlap Syndromes Chapter 16. Chronic Myelomonocytic Leukemia PART V: ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES Chapter 17. Acute Myeloid Leukemia Chapter 18. Secondary AML and AML With Myelodysplasia-Related Changes Chapter 19. Acute Promyelocytic Leukemia Chapter 20. Blastic Plasmacytoid Dendritic Cell Neoplasm PART VI: ACUTE LYMPHOID LEUKEMIA Chapter 21. B-Lymphoblastic Leukemia/Lymphoma Chapter 22. BCR-ABL1 B-Lymphoblastic Leukemia Chapter 23. T-Lymphoblastic Lymphoma/Leukemia PART VII: ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE Chapter 24. Acute Leukemia of Ambiguous Lineage PART VIII: MATURE T- AND NK-CELL LEUKEMIA Chapter 25. T-Cell Prolymphocytic Leukemia Chapter 26. T-Cell Large Granular Lymphocytic Leukemia Chapter 27. Aggressive Natural Killer Cell Leukemia PART IX: PLASMA CELL DISORDERS Chapter 28. Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas Chapter 29. Multiple Myeloma Chapter 30. Waldenstroem’s Macroglobulinemia Chapter 31. Immunoglobulin Light Chain Amyloidosis PART X: HODGKIN LYMPHOMA Chapter 32. Hodgkin Lymphoma PART XI: NON-HODGKIN LYMPHOMA Chapter 33. Non-Hodgkin Lymphoma Classification and Diagnostic Evaluation PART XII: MATURE B-CELL LYMPHOMA VERY AGGRESSIVE Chapter 34. Burkitt Lymphoma AGGRESSIVE Chapter 35. Diffuse Large B-Cell Lymphoma Chapter 36. Double Hit Lymphoma Chapter 37. Mantle Cell Lymphoma Chapter 38. Primary Mediastinal Large B-Cell Lymphoma Chapter 39. Primary Central Nervous System Lymphoma Chapter 40. HIV-Related Lymphomas INDOLENT Chapter 41. Follicular Lymphoma Chapter 42. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Chapter 43. Hairy Cell Leukemia Chapter 44. Marginal Zone Lymphoma Chapter 45. Mucosa-Associated Lymphoid Tissue Lymphoma PART XIII: MATURE T/NK-CELL LYMPHOMA Chapter 46. Adult T-Cell Leukemia/Lymphoma Chapter 47. Anaplastic Large Cell Lymphoma, ALK Positive Chapter 48. Extranodal Natural Killer/T-Cell Lymphoma Chapter 49. Mycosis Fungoides Chapter 50. Hepatosplenic T-Cell Lymphoma PART XIV: HISTIOCYTIC/DENDRITIC CELL NEOPLASMS Chapter 51. Histiocytic Sarcoma, Langerhans Cell Histiocytosis, Erdheim-Chester Disease, and Rosai-Dorfman Disease Chapter 52. Hemophagocytic Lymphohistiocytosis PART XV: BONE MARROW TRANSPLANTATION Chapter 53. Autologous Bone Marrow Transplantation Chapter 54. Allogeneic Bone Marrow Transplantation PART XVI: NEW CELLULAR IMMUNOTHERAPY Chapter 55. CAR-T and Novel Cellular Therapeutic Options in Hematologic Malignancies Chapter 56. CD19 CAR-T Therapy Chapter 57. Cytokine Release Syndrome PART XVII: EMERGENCIES IN HEMATOLOGY Chapter 58. Cancer Associated Thrombosis Chapter 59. Tumor Lysis Syndrome Chapter 60. Thrombotic Microangiopathy Chapter 61. Therapeutic Apheresis Indications PART XVIII: NEW CLINICAL CASES IN MALIGNANT HEMATOLOGY Chapter 62. Challenging Case Vignettes with Follow-Up Questions Appendix: Pathology Supplement

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