图书简介
The present medical sciences identify pathological hypoxia as etiological as well as causative in a wide range of diseases such as cancers and tumors, cardiovascular distress, high altitude diseases, pulmonary fibrosis, and pulmonary viral infections. Moreover, this component of hypoxia creates a molecular milieu which adds to robustness of the disease phenotype, limiting the efficacy of therapeutic interventions and at the same time triggering a cascade of pro-oxidant, pro-inflammatory mediators further exaggerating the disease. It has been noticed that the smart nanomaterials have revolutionized diagnostics, imaging, drug delivery, and therapeutic formulations with enhanced efficacy in disease management. This book showcases the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings, by various experts in the field. Overall, the themes in the book touch upon critical facets to address pathological hypoxia—nanomaterials enhancing oxygenation, hypoxia responsive nano-formulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nano-formulations to counter molecular consequences of hypoxia, theranostic combining hypoxia detection systems with drug delivery systems, etc. The book covers a wide range of concepts and new age advancements in the field of “intelligent” nanomaterials relevant to health care and is widely useful for the students, researchers, industry experts, and academia.
Bio-inspired nano systems interacting with the host environment: smart nano systems.- Recent progress in hypoxia-targeting: peptide-based nanomaterials.- New developments in nanotheranostics combined with intelligent bioresponsive systems.- Recent advancements in the field of stimuli-responsive nanopolymers for cancer treatment.- Novel Strategies to repress tumor hypoxia for the enhancement of cancer therapy.- Anopoxia: Antimonene-based nanoplatform for precision cancer therapy targeting cancer hypoxia.- Efficacy of diverse oxygen delivering nanoparticles in vitro and in animal models for treating hypoxia.- Anoproteomic: An approach for the identification of molecular targets associated with hypoxia.- Advances of nanomaterial with hypoxia inducible factor in periodontal inflammation.- ROS responsive silica nanoparticles for controlled and targeted drug delivery.- Tissue oxygenation and pH responsive fluorescent nano sensors in tumour diagnosis.- Hypoxia responsive nanomaterials for cerebral ischemia diagnosis.- Multifunctional hypoxia imaging nanoparticles.- Anaerobic bacteria mediated hypoxia-specific delivery of nanoparticles.- Reversible switch ON-OFF responsive nanoparticles in hypoxia management.
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