图书简介

Chapter 1: Definition, History, Nosology, and Classification; Introduction and Definition; Brief History of PD; Nosology and Classification Scheme; Classification Level 1; Classification Level 2; Ambiguities and Future Directions; Conclusion; Chapter 2: Epidemiology; Introduction; Prevalence; Incidence; Mortality; Risk Factors; Implications for Understanding Etiopathogenesis and the Future Burden of PD; Chapter 3: Pathology; Introduction; The Aging Brain; Gross Pathology, Lewy Pathology, and a-Synucleinopathy; Substantia Nigra Pars Compacta Pathology; Idiopathic Lewy Body Disease (iLBD); The Braak et al. Staging System; Synucleinopathy Outside the Brain; Non-Synuclein Pathologies; Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model; Introduction; Basic Basal Ganglia Architecture; The Standard Model of Basal Ganglia Pathophysiology; Complexities of Basal Ganglia Architecture; Conclusion; Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions; Introduction; Nigrostriatal Dopamine Signaling Functions; Habit Formation and Chunking; Cholinergic Projection System Dysfunctions; Serotoninergic System Dysfunctions; Conclusions and Future Challenges; Chapter 6: Genetics of Parkinson Disease; Introduction; Dominant Forms of PD; Recessive Forms of PD; GBA; PD Genetic Risk Factors; Implications of PD Genetic Research; Chapter 7: Pathogenesis; Neuronal Vulnerability; Alpha-Synuclein; The Prion-Like Hypothesis; Mitochondrial Dysfunction; Oxidative Stress; Endolysosomal Dysfunction; Neuroinflammation; Neuroprotection Trials; Conclusions; Chapter 8: Prodromal Parkinson Disease; Introduction; REM Sleep Behavior Disorder; Observational Studies; REM Sleep Behavior Disorder Cohort Studies; Genetic Cohort Studies; Autonomic Failure; Future Directions; Chapter 9: Clinical Features I - Initial Evaluation; Presentation Features; Nature of Diagnosis and Diagnostic Criteria; History and Examination; Differential Diagnosis; Treatment Responsiveness; Diagnostic Accuracy; Chapter 10: Clinical Features II - Non-Motor Features; Introduction; Cognitive Impairments; Neuropsychiatric Disorders; Sleep Disorders; Pain; Fatigue; Autonomic Disorders; Visual Disorders; Oral Health; Conclusion; Chapter 11: Clinical Features III - Natural History ; Introduction; Assessing PD Progression; PD Progression - Clinically Salient Features; Subgroups; Natural History Summary; Continuing Care; End of Life Care; Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics; Introduction; Dopaminergic Neurotransmission; L-Dopa Pharmacokinetics; L-Dopa Pharmacodynamics; Peak Dose Dyskinesias; Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions; Chapter 13: Pharmacology II - Treating Parkinson Disease; Introduction; Using L-Dopa; When the Honeymoon Is Over; L-Dopa Adjuncts; Dopamine Agonists; Cholinergic Agents; Other Symptomatic Therapies; Future Directions; Chapter 14: Surgery; Introduction; Deep Brain Stimulation: Rationale and Possible Mechanisms; Deep Brain Stimulation: Procedures; Deep Brain Stimulation: STN DBS Benefits; Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS; Deep Brain Stimulation: Adverse Events; Lesional Procedures; Cell-Based and Gene Therapies; Future Directions; Coda: Looking Ahead

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