图书简介

Table of Contents; Preface to the Second Edition; Preface to the First Edition; Abbreviations; Chapter 1. Introduction; The Fundamentals Still Pertain; Principles of Effective and Efficient Programming; The Basis of DBS Effects; Chapter 2. Principles of DBS Electronics; Electricity; Electronics; Note Regarding Impedances; Chapter 3. Principles of Electrophysiology; Therapeutic Mechanisms versus Delivery of Therapy; The Neuron; Neuronal Electronics; Voltage Gated Ionic Conductance Channels and Action Potentials; Downstream Secondary Issues; Chapter 4. Controlling the Flow of Electrical Charges; Orientation of the Lines of Electrical Force; Orthodromic and Antidromic Conduction of Action Potentials; Axon Diameter; Electrode Configurations; Current Intensity in Monopolar and Bipolar Electrode Configurations; Segmented DBS Leads; Chapter 5. DBS Safety; The Range of Safety Concerns; Injury Secondary to Electricity; Medical Complications; Adverse Effects Related to Activation of Neural Networks; The Potential Psychosocial Consequences of DBS; Chapter 6. Nervous System Responses to DBS; Knowledge of Nervous System Responses versus Knowledge of Therapeutic Mechanisms; Effects Mediated by Voltage-Gated Ionic Conductance Channels in the Neuronal Membrane; Post-Hyperpolarization Rebound Excitation, Depolarization Blockade, and Neurotransmitter Exhaustion; Dissociation of Effects on Action Potential Initiating Segment, Dendrites, and Cell Bodies; Network Effects of DBS; Critically Important Caveats Concerning Interpretation of Nervous System Responses to DBS; Reentry Propagations and Resonance; Synchronization Among Neurons; Interactions Between DBS Pulse in Intrinsic Neuronal Mechanisms; Effects on Behaviorally Related Intrinsic Neuronal Dynamic; Temporal Evolution of Nervous System Responses; Chapter 7. DBS Effects on Motor Control; Orchestration of Motor Unit Activities; Orchestration of Motor Unit Recruitment and De-Recruitment over Different Time Scales; Lessons to be Learned; Chapter 8. Pathophysiological Mechanisms; The Globus Pallidus Interna Rate Theory; Excessively High Beta Oscillations; Excessive Synchronization of Neuronal Activities; Excessive Bursting; The Systems Oscillators Theory; Chapter 9. Approaches to Programming; Battery Life; DBS Contact Nomenclature; Prior to DBS Programming; When to Program DBS; Conceptual Approaches; The Growing Importance of Monopolar Surveys; Detection of a Response is Critical; Programming for Optimal Benefit in the Absence of Adverse Effects; Programming to Prevent Adverse Effects; Exiting the DBS Programming Session; Chapter 10. Clinical Assessments; Clinical Assessments by Disease; Clinical Assessment of Corticospinal and Corticobulbar Stimulation; Clinical Assessment of Speech, Language and Swallowing; Hints to Clinical Evaluations; Chapter 11. Approach to Subthalamic Nucleus; Regional Anatomy of the Subthalamic Nucleus; Adverse Effects Created by the Position of the DBS Lead Relative to the STN; Approach to STN DBS for Parkinson’s Disease; Chapter 12. Approach to Globus Pallidus Internal; Regional Anatomy of the Globus Pallidus Internal (GPi) Segment; Adverse Effects Resulting from the Position of the DBS Lead Relative to the GPi; Approaches to GPi DBS for Parkinson’s Disease; Treating Dystonia with DBS of the Globus Pallidus Interna; Treating Hyperkinetic Disorders; Chapter 13. Approach to Thalamic DBS; Regional Anatomy of the Ventral Intermediate Thalamus; Adverse Effects Resulting from the Position of the DBS Lead Relative to the Ventral; Effects of DBS on Speech and Swallowing; An Approach to Thalamic DBS for Tremor; Chapter 14. Algorithm for Selecting Electrode Configurations and; Stimulation Parameters; Chapter 15. Helpful Programming Hints; Use of Constant-Voltage DBS (to be discouraged); Conduct a Monopolar Survey; Always Increase the Voltage to Clarify Any Side Effects; Check Therapeutic Impedances on Commercial IPGs; Confirm that the Parameters under Patient Control are within Safe Limits; Systematically Document all Clinical Responses to all DBS Stimulation Parameters and Electrode Configurations; Always Reset Counters and Trouble-Shoot Inconsistent Responses; Advise Patents, Family Members and Caregivers to Take Their DBS Controlling Devices with Them to Emergency Rooms or Doctor’s Visits; Be Patient and Persistent!; When in Doubt, Turn the Pulse Generator Off and Wait; Trouble Shooting; Chapter 16. Oscillator Basics; Chapter 17. Discrete Neural Oscillators; Importance of Neural Oscillators in Nervous System Function; Continuous harmonic oscillators; Discrete Oscillators; Single Reentrant Discrete Oscillator; Interactions Among Discrete Oscillators; Discrete Neural Oscillators; Oscillators with multiple realistic neurons; The Systems (Discrete) Oscillators Theory; Appendix of Supplemental Material; Glossary; References

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