Approaching Complex Diseases:Network-Based Pharmacology and Systems Approach in Bio-Medicine（Human Perspectives in Health Sciences and Technology）
探讨复杂疾病：基于网络的生物医学药理学与系统方法
药理学售 价：
￥
2600.00
发货周期：外国库房发货，通常付款后3-5周到货
作 者
出版时间
2020年04月18日
装 帧
精装
页 码
565
语 种
英文
版 次
2020
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图书简介
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
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