The ? rst edition of Human Genetics, Problems and Approaches , was published in 1970 by human geneticists Friedrich Vogel and Arno Motulsky as sole authors. The aim was broad coverage and in-depth analysis of both medical and human genetics with an emphasis on problems and approaches with occasional historical c- ments. This point of view was fully explained in an introductory chapter of the three previous editions (1970, 1976, 1997). The book acquired an excellent reputation as an advanced text of human genetics and has been translated into Italian, Japanese, Russian, Chinese, and Portuguese. Our general aims for the fourth edition remain similar and together with novel developments are now set out in the Introduction of this new fourth edition. Around 2004/2005, both Friedrich Vogel and Arno Motulsky, as well as the publishers, felt that the book should be continued with a new fourth edition in the same spirit and coverage as earlier editions, but should now include additional expert authors. After some delay and the death of Friedrich Vogel in the summer of 2006, a new editorial team consisting of Michael R. Speicher of the Medical University of Graz, Austria, Stylianos E. Antonarakis of the University of Geneva Medical School, and Arno G. Motulsky of the University of Washington School of Medicine, was constituted for the fourth edition of the Vogel/Motulsky book in the spirit of the original work.

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