图书简介
It was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. This book focuses on this group of imaging reporter genes and includes discussion of imaging modalities, enhancing imaging utility, the various applications of this technology, and the future of the field.
Part I. Types of Imaging Reporter Genes: 1. Fluorescent proteins reporter Robert E. Campbell and Michael W. Davidson; 2. Revealing biomolecular mechanisms through in vivo bioluminescence imaging Timothy C. Doyle, Qian Wang, and Christopher H. Contag; 3. Reporter gene imaging with PET/SPECT June-Key Chung, Joo Hyun Kang, and Keon Wook Kang; 4. Non-invasive imaging genes and gene expression with magnetic resonance imaging and magnetic resonance spectroscopy James Basilion; Part II. Enhancing Reporter Gene Imaging Techniques: 5. Multimodality imaging reporter gene Pritha Ray and Sanjiv Sam Gambhir; 6. Cell-specific imaging of reporter gene expression using a two-step transcriptional amplification strategy Marxa L. Figueirdo, Sanjiv Sam Gambhir, Michael Carey, and Lily Wu; Part III. Imaging Instrumentations: 7. Physics, instrumentation, and methods for imaging reporter gene expression in living subjects Craig S. Levin; Part IV. Current Applications of Imaging Reporter Genes: 8. Reporter gene imaging of cell signal transduction Tarik F. Massoud, Ramasamy Paulmurugan, Carmel Chan, Hua Fan-Minogue, and Sanjiv Sam Gambhir; 9. Gene therapy and imaging of transgene expression in living subjects Shahrihar S. Yaghoubi and Sanjiv Sam Gambhir; 10. Imaging regulation of endogenous gene expression in living subjects Vladimir Ponomarev; 11. Imaging cell trafficking and immune cell activation using PET reporter genes Evan D. Nair-Gill, Chengyi J. Shu, Isabel J. Hildebrandt, Dean O. Campbell, Owen N. Witte, and Caius G. Radu; 12. Imaging reporter genes and stem cells Martin G. Rodriguez-Porcel; 13. Clinical applications of reporter gene technology Ivan Penuelas, Shahriar S. Yaghoubi, Felipe Prosper, and Sanjiv Sam Gambhir.
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