图书简介
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems-Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
Foreword Preface Contributors 1 Electron Cryotomography of Bacterial Secretion Systems Catherine M. Oikonomou and Grant J. Jensen 2 SecA-Mediated Protein Translocation through the SecYEG Channel Amalina Ghaisani Komarudin and Arnold J.M. Driessen 3 The Two Distinct Types of SecA2-Dependent Export Systems Miriam Braunstein, Barbara A. Bensing, and Paul M. Sullam 4 The Conserved Role of YidC in Membrane Protein Biogenesis Sri Karthika Shanmugam and Ross E. Dalbey 5 The Twin-Arginine Pathway for Protein Secretion Kelly M. Frain, Jan Maarten van Dijl, and Colin Robinson 6 Lipoproteins and Their Trafficking to The Outer Membrane Marcin Grabowicz 7 Protein Secretion in Spirochetes Wolfram R. Zuckert 8 Outer Membrane Protein Insertion by the -barrel Assembly Machine Dante P. Ricci and Thomas J. Silhavy 9 The TAM: A Translocation and Assembly Module of the -barrel Assembly Machinery in Bacterial Outer Membranes Christopher J. Stubenrauch and Trevor Lithgow 10 The Dynamic Structures of the Type IV Pilus Matthew McCallum, Lori L. Burrows, and P. Lynne Howell 11 Gram-Positive Type IV Pili and Competence Sandra Muschiol, Marie-Stephanie Aschtgen, Priyanka Nannapaneni, and Birgitta Henriques-Normark 12 The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective Manuela K. Hospenthal and Gabriel Waksman 13 Therapeutic Approaches Targeting the Assembly and Function of Chaperone-Usher Pili John J. Psonis and David G. Thanassi 14 Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion Pathway Sujeet Bhoite, Nani van Gerven, Matthew R. Chapman, and Han Remaut 15 Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development Olaf Schneewind and Dominique Missiakas 16 Architecture and Assembly of Periplasmic Flagellum Yunjie Chang and Jun Liu 17 Outer Membrane Vesicle-Host Cell Interactions Jessica D. Cecil, Natalie Sirisaengtaksin, Neil M. O’Brien-Simpson, and Anne Marie Krachler 18 Type I Secretion Systems-One Mechanism for All? Olivia Spitz, Isabelle N. Erenburg, Tobias Beer, Kerstin Kanonenberg, I. Barry Holland, and Lutz Schmitt 19 Architecture, Function, and Substrates of the Type II Secretion System Konstantin V. Korotkov and Maria Sandkvist 20 The Injectisome, A Complex Nanomachine for Protein Injection into Mammalian Cells Maria Lara-Tejero and Jorge E. Galan 21 Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target Alyssa C. Fasciano, Lamyaa Shaban, and Joan Mecsas 22 Biological and Structural Diversity of Type IV Secretion Systems Yang Grace Li, Bo Hu, and Peter J. Christie 23 Hostile Takeover: Hijacking of Endoplasmic Reticulum Function by T4SS and T3SS Effectors Creates a Niche for Intracellular Pathogens April Y. Tsai, Bevin C. English, and Renee M. Tsolis 24 Type V Secretion in Gram-Negative Bacteria Harris D. Bernstein 25 Bordetella Filamentous Hemagglutinin, A Model for the Two-Partner Secretion Pathway Zachary M. Nash and Peggy A. Cotter 26 Structure and Activity of the Type VI Secretion System Yassine Cherrak, Nicolas Flaugnatti, Eric Durand, Laure Journet, and Eric Cascales 27 Type VI Secretion Systems and the Gut Microbiota Michael J. Coyne and Laurie E. Comstock 28 ESX / Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins Farzam Vaziri and Roland Brosch 29 Bacteroidetes Gliding Motility and the Type IX Secretion System Mark J. McBride 30 Similarities and Differences between Colicin and Filamentous Phage Uptake by Bacterial Cells Denis Duche and Laetitia Houot 31 A Hybrid Secretion System Facilitates Bacterial Sporulation: A Structural Perspective Natalie Zeytuni and Natalie C.J. Strynadka Index
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